Regulation of calcium currents by chemokines and their receptors.
Publication
, Journal Article
Oh, SB; Endoh, T; Simen, AA; Ren, D; Miller, RJ
Published in: Journal of neuroimmunology
February 2002
We investigated the modulation of voltage dependent Ca(2+) currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1alpha, RANTES and MDC inhibited the I(Ba) in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The I(Ba) inhibition was voltage-dependent, exhibited prepulse facilitation, and was blocked by N-ethylmaleimide and pertussis toxin pretreatment, indicating that it was mediated by Gi/Go. Some chemokines also inhibited the I(Ba) in subpopulations of dorsal root ganglion neurons and area postrema/nucleus tractus solitarius neurons. These data provide evidence that chemokines can potentially modulate neuronal signaling through the inhibition of neuronal Ca(2+) currents.
Duke Scholars
Published In
Journal of neuroimmunology
DOI
EISSN
1872-8421
ISSN
0165-5728
Publication Date
February 2002
Volume
123
Issue
1-2
Start / End Page
66 / 75
Related Subject Headings
- Receptors, Chemokine
- Receptors, Cell Surface
- Rats
- Neurons
- Neurology & Neurosurgery
- Heterotrimeric GTP-Binding Proteins
- GTP-Binding Protein alpha Subunits, Gi-Go
- Female
- Chemokines
- Cell Line
Citation
APA
Chicago
ICMJE
MLA
NLM
Oh, S. B., Endoh, T., Simen, A. A., Ren, D., & Miller, R. J. (2002). Regulation of calcium currents by chemokines and their receptors. Journal of Neuroimmunology, 123(1–2), 66–75. https://doi.org/10.1016/s0165-5728(01)00485-4
Oh, Seog Bae, Takayuki Endoh, Arthur A. Simen, Dongjun Ren, and Richard J. Miller. “Regulation of calcium currents by chemokines and their receptors.” Journal of Neuroimmunology 123, no. 1–2 (February 2002): 66–75. https://doi.org/10.1016/s0165-5728(01)00485-4.
Oh SB, Endoh T, Simen AA, Ren D, Miller RJ. Regulation of calcium currents by chemokines and their receptors. Journal of neuroimmunology. 2002 Feb;123(1–2):66–75.
Oh, Seog Bae, et al. “Regulation of calcium currents by chemokines and their receptors.” Journal of Neuroimmunology, vol. 123, no. 1–2, Feb. 2002, pp. 66–75. Epmc, doi:10.1016/s0165-5728(01)00485-4.
Oh SB, Endoh T, Simen AA, Ren D, Miller RJ. Regulation of calcium currents by chemokines and their receptors. Journal of neuroimmunology. 2002 Feb;123(1–2):66–75.
Published In
Journal of neuroimmunology
DOI
EISSN
1872-8421
ISSN
0165-5728
Publication Date
February 2002
Volume
123
Issue
1-2
Start / End Page
66 / 75
Related Subject Headings
- Receptors, Chemokine
- Receptors, Cell Surface
- Rats
- Neurons
- Neurology & Neurosurgery
- Heterotrimeric GTP-Binding Proteins
- GTP-Binding Protein alpha Subunits, Gi-Go
- Female
- Chemokines
- Cell Line