Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.
Publication
, Journal Article
Lee, E; Sivalingam, J; Lim, ZR; Chia, G; Shi, LG; Roberts, M; Loh, Y-H; Reuveny, S; Oh, SK-W
Published in: Biotechnology advances
December 2018
In vitro generation of red blood cells (RBCs) has the potential to circumvent the shortfalls in global demand for blood for transfusion applications. The conventional approach for RBC generation has been from differentiation of hematopoietic stem cells (HSCs) derived from cord blood, adult bone marrow or peripheral blood. More recently, RBCs have been generated from human induced pluripotent stem cells (hiPSCs) as well as from immortalized adult erythroid progenitors. In this review, we highlight the recent advances to RBC generation from these different approaches and discuss the challenges and new strategies that can potentially make large-scale in vitro generation of RBCs a feasible approach.
Duke Scholars
Published In
Biotechnology advances
DOI
EISSN
1873-1899
ISSN
0734-9750
Publication Date
December 2018
Volume
36
Issue
8
Start / End Page
2118 / 2128
Related Subject Headings
- Transfusion Medicine
- Mice
- Induced Pluripotent Stem Cells
- Humans
- Hematopoietic Stem Cells
- Fetal Blood
- Erythrocytes
- Cell Differentiation
- Cell Culture Techniques
- Biotechnology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, E., Sivalingam, J., Lim, Z. R., Chia, G., Shi, L. G., Roberts, M., … Oh, S.-W. (2018). Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnology Advances, 36(8), 2118–2128. https://doi.org/10.1016/j.biotechadv.2018.09.006
Lee, Esmond, Jaichandran Sivalingam, Zhong Ri Lim, Gloryn Chia, Low Gin Shi, Mackenna Roberts, Yuin-Han Loh, Shaul Reuveny, and Steve Kah-Weng Oh. “Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.” Biotechnology Advances 36, no. 8 (December 2018): 2118–28. https://doi.org/10.1016/j.biotechadv.2018.09.006.
Lee E, Sivalingam J, Lim ZR, Chia G, Shi LG, Roberts M, et al. Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnology advances. 2018 Dec;36(8):2118–28.
Lee, Esmond, et al. “Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.” Biotechnology Advances, vol. 36, no. 8, Dec. 2018, pp. 2118–28. Epmc, doi:10.1016/j.biotechadv.2018.09.006.
Lee E, Sivalingam J, Lim ZR, Chia G, Shi LG, Roberts M, Loh Y-H, Reuveny S, Oh SK-W. Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges. Biotechnology advances. 2018 Dec;36(8):2118–2128.
Published In
Biotechnology advances
DOI
EISSN
1873-1899
ISSN
0734-9750
Publication Date
December 2018
Volume
36
Issue
8
Start / End Page
2118 / 2128
Related Subject Headings
- Transfusion Medicine
- Mice
- Induced Pluripotent Stem Cells
- Humans
- Hematopoietic Stem Cells
- Fetal Blood
- Erythrocytes
- Cell Differentiation
- Cell Culture Techniques
- Biotechnology