Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.
Publication
, Journal Article
Low, J-L; Jürjens, G; Seayad, J; Seow, J; Ting, S; Laco, F; Reuveny, S; Oh, S; Chai, CLL
Published in: Bioorganic & medicinal chemistry letters
June 2013
The p38α mitogen-activated protein kinase (MAPK) inhibitor SB203580 had been reported to enhance the cardiomyogenesis of human embryonic stem cells (hESCs). To investigate if tri-substituted imidazole analogues of SB203580 are equally effective inducers for cardiomyogenesis of hESCs, and if there is a correlation between p38α MAPK inhibition and cardiomyogenesis, we designed and synthesized a series of novel tri-substituted imidazoles with a range of p38α MAPK inhibitory activities. Our studies demonstrated that suitably designed analogues of SB203580 can also be inducers of cardiomyogenesis in hESCs and that cell growth is affected by changes in the imidazole structures.
Duke Scholars
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
June 2013
Volume
23
Issue
11
Start / End Page
3300 / 3303
Related Subject Headings
- Pyridines
- Protein Binding
- Myocytes, Cardiac
- Mitogen-Activated Protein Kinase 14
- Medicinal & Biomolecular Chemistry
- Imidazoles
- Humans
- Embryonic Stem Cells
- Cell Differentiation
- 3405 Organic chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Low, J.-L., Jürjens, G., Seayad, J., Seow, J., Ting, S., Laco, F., … Chai, C. L. L. (2013). Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. Bioorganic & Medicinal Chemistry Letters, 23(11), 3300–3303. https://doi.org/10.1016/j.bmcl.2013.03.103
Low, Joo-Leng, Gerrit Jürjens, Jayasree Seayad, Jasmine Seow, Sherwin Ting, Filip Laco, Shaul Reuveny, Steve Oh, and Christina L. L. Chai. “Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.” Bioorganic & Medicinal Chemistry Letters 23, no. 11 (June 2013): 3300–3303. https://doi.org/10.1016/j.bmcl.2013.03.103.
Low J-L, Jürjens G, Seayad J, Seow J, Ting S, Laco F, et al. Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. Bioorganic & medicinal chemistry letters. 2013 Jun;23(11):3300–3.
Low, Joo-Leng, et al. “Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.” Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 11, June 2013, pp. 3300–03. Epmc, doi:10.1016/j.bmcl.2013.03.103.
Low J-L, Jürjens G, Seayad J, Seow J, Ting S, Laco F, Reuveny S, Oh S, Chai CLL. Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells. Bioorganic & medicinal chemistry letters. 2013 Jun;23(11):3300–3303.
Published In
Bioorganic & medicinal chemistry letters
DOI
EISSN
1464-3405
ISSN
0960-894X
Publication Date
June 2013
Volume
23
Issue
11
Start / End Page
3300 / 3303
Related Subject Headings
- Pyridines
- Protein Binding
- Myocytes, Cardiac
- Mitogen-Activated Protein Kinase 14
- Medicinal & Biomolecular Chemistry
- Imidazoles
- Humans
- Embryonic Stem Cells
- Cell Differentiation
- 3405 Organic chemistry