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Current State of Evidence for Use of MRI in LI-RADS.

Publication ,  Journal Article
Kulkarni, AM; Kruse, D; Harper, K; Lam, E; Osman, H; Ansari, DH; Sivanesan, U; Bashir, MR; Costa, AF; McInnes, M; van der Pol, CB
Published in: J Magn Reson Imaging
September 2025

The American College of Radiology Liver Imaging Reporting and Data System (LI-RADS) is the preeminent framework for classification and risk stratification of liver observations on imaging in patients at high risk for hepatocellular carcinoma. In this review, the pathogenesis of hepatocellular carcinoma and the use of MRI in LI-RADS is discussed, including specifically the LI-RADS diagnostic algorithm, its components, and its reproducibility with reference to the latest supporting evidence. The LI-RADS treatment response algorithms are reviewed, including the more recent radiation treatment response algorithm. The application of artificial intelligence, points of controversy, LI-RADS relative to other liver imaging systems, and possible future directions are explored. After reading this article, the reader will have an understanding of the foundation and application of LI-RADS as well as possible future directions.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

September 2025

Volume

62

Issue

3

Start / End Page

640 / 653

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiology Information Systems
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Interpretation, Computer-Assisted
  • Humans
  • Evidence-Based Medicine
  • Carcinoma, Hepatocellular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kulkarni, A. M., Kruse, D., Harper, K., Lam, E., Osman, H., Ansari, D. H., … van der Pol, C. B. (2025). Current State of Evidence for Use of MRI in LI-RADS. J Magn Reson Imaging, 62(3), 640–653. https://doi.org/10.1002/jmri.29748
Kulkarni, Ameya Madhav, Danielle Kruse, Kelly Harper, Eric Lam, Hoda Osman, Danyaal H. Ansari, Umaseh Sivanesan, et al. “Current State of Evidence for Use of MRI in LI-RADS.J Magn Reson Imaging 62, no. 3 (September 2025): 640–53. https://doi.org/10.1002/jmri.29748.
Kulkarni AM, Kruse D, Harper K, Lam E, Osman H, Ansari DH, et al. Current State of Evidence for Use of MRI in LI-RADS. J Magn Reson Imaging. 2025 Sep;62(3):640–53.
Kulkarni, Ameya Madhav, et al. “Current State of Evidence for Use of MRI in LI-RADS.J Magn Reson Imaging, vol. 62, no. 3, Sept. 2025, pp. 640–53. Pubmed, doi:10.1002/jmri.29748.
Kulkarni AM, Kruse D, Harper K, Lam E, Osman H, Ansari DH, Sivanesan U, Bashir MR, Costa AF, McInnes M, van der Pol CB. Current State of Evidence for Use of MRI in LI-RADS. J Magn Reson Imaging. 2025 Sep;62(3):640–653.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

September 2025

Volume

62

Issue

3

Start / End Page

640 / 653

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiology Information Systems
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Interpretation, Computer-Assisted
  • Humans
  • Evidence-Based Medicine
  • Carcinoma, Hepatocellular