Nephrology

Patients with renal diseases have their own particular complications of hemostasis and thrombosis. Bleeding and platelet dysfunction is a common complication of chronic kidney disease and uremia. Similarly, coagulation activation and risk of thrombosis is also greater in chronic kidney disease. Nephrotic syndrome and antineutrophil cytoplasmic antibodies vasculitis are also associated with an increased risk of thrombosis. Renal transplant patients also have more frequent thromboembolic events; thrombosis of the graft may lead to loss of the transplanted organ. Lastly, the use of anticoagulation, both injectable and oral, must be tempered in the setting of reduced kidney function.

Duke Scholars

Author Thomas Lee Ortel Medicine, Hematology