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Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging.

Publication ,  Journal Article
De Santis, D; Del Gaudio, A; Santangeli, C; Fanelli, F; Pacelli, F; Capece Minutolo Del Sasso, L; Zerunian, M; Polici, M; Polidori, T; Marin, D ...
Published in: Invest Radiol
October 1, 2025

Photon-counting detector computed tomography (PCD-CT) is a breakthrough innovation over conventional single-energy and dual-energy CT equipped with energy-integrating detectors (EID). Because of increased spatial resolution and improved material differentiation, PCD-CT aims at improving the diagnosis of various abdominal conditions. This technology offers several advantages over EID-based CT scanners, including higher spatial and contrast resolution, reduced electronic noise, and low radiation dose exposure. Additionally, because spectral information is generated within the detectors, PCD-CT offers the possibility of routine spectral examinations and refines material decomposition through available multienergy imaging, further enhancing tissue characterization and image contrast. With most scientific literature focused on cardiovascular applications, abdominal imaging is an open field for technical and clinical research in PCD-CT. This review aims to provide a general overview of the technical principles of PCD-CT, its applications in abdominal imaging, and to summarize the main literature findings of its clinical applications in the liver, pancreas, adrenals, genitourinary system, bowel, peritoneum, and abdominal vessels. We will also highlight the pros and cons observed in clinical practice and offer insights into potential future developments of PCD-CT in abdominal imaging.

Duke Scholars

Published In

Invest Radiol

DOI

EISSN

1536-0210

Publication Date

October 1, 2025

Volume

60

Issue

10

Start / End Page

647 / 657

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiography, Abdominal
  • Radiation Dosage
  • Photons
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Forecasting
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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De Santis, D., Del Gaudio, A., Santangeli, C., Fanelli, F., Pacelli, F., Capece Minutolo Del Sasso, L., … Caruso, D. (2025). Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging. Invest Radiol, 60(10), 647–657. https://doi.org/10.1097/RLI.0000000000001178
De Santis, Domenico, Antonella Del Gaudio, Curzio Santangeli, Federica Fanelli, Fiammetta Pacelli, Lucrezia Capece Minutolo Del Sasso, Marta Zerunian, et al. “Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging.Invest Radiol 60, no. 10 (October 1, 2025): 647–57. https://doi.org/10.1097/RLI.0000000000001178.
De Santis D, Del Gaudio A, Santangeli C, Fanelli F, Pacelli F, Capece Minutolo Del Sasso L, et al. Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging. Invest Radiol. 2025 Oct 1;60(10):647–57.
De Santis, Domenico, et al. “Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging.Invest Radiol, vol. 60, no. 10, Oct. 2025, pp. 647–57. Pubmed, doi:10.1097/RLI.0000000000001178.
De Santis D, Del Gaudio A, Santangeli C, Fanelli F, Pacelli F, Capece Minutolo Del Sasso L, Zerunian M, Polici M, Polidori T, Pucciarelli F, Marin D, Laghi A, Caruso D. Every Drop (Photon) Counts: Current Applications and Future Challenges of Photon-Counting Detector CT in Abdominal Imaging. Invest Radiol. 2025 Oct 1;60(10):647–657.

Published In

Invest Radiol

DOI

EISSN

1536-0210

Publication Date

October 1, 2025

Volume

60

Issue

10

Start / End Page

647 / 657

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Radiography, Abdominal
  • Radiation Dosage
  • Photons
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Forecasting
  • 3202 Clinical sciences
  • 1103 Clinical Sciences