Thalamic Tumors

Tumors arising from the thalamus are relatively rare and predominantly composed of low- and high-grade gliomas. Given their deep location, careful consideration of resection or biopsy must be made. If the lesion is determined to be amenable to surgical resection, there are numerous operative corridor options to minimize morbidity and maximize visualization. Further, these lesions often present with concomitant obstructive hydrocephalus, which must be managed expeditiously. Recently, the genetic drivers of many thalamus gliomas have been elucidated, including K27M mutations, BRAF mutations and fusions, and others, which not only provide insight into their oncogenesis, but also reveal potential therapeutic targets.

Duke Scholars

Author Stephen Harward Neurosurgery