Textbook of Diabetes Fifth Edition
Glucagon in Islet and Metabolic Regulation
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, Chapter
Sandoval, D; Tong, J; D'Alessio, D
January 1, 2016
Glucagon is predominantly made in islet α cells and regulates systemic glycemia primarily through actions in the liver. Beyond endocrine actions in glucose counter-regulation and metabolism of protein rich meals, glucagon may have roles in paracrine regulation of islet function and energy balance. Excess glucagon contributes to dysglycemia in persons with diabetes and has a central role in diabetic ketoacidosis. Compounds that stimulate and block the glucagon receptor are under investigation for the treatment of metabolic disorders.
Duke Scholars
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Sandoval, D., Tong, J., & D’Alessio, D. (2016). Glucagon in Islet and Metabolic Regulation. In Textbook of Diabetes Fifth Edition (pp. 103–113). https://doi.org/10.1002/9781118924853.ch7
Sandoval, D., J. Tong, and D. D’Alessio. “Glucagon in Islet and Metabolic Regulation.” In Textbook of Diabetes Fifth Edition, 103–13, 2016. https://doi.org/10.1002/9781118924853.ch7.
Sandoval D, Tong J, D’Alessio D. Glucagon in Islet and Metabolic Regulation. In: Textbook of Diabetes Fifth Edition. 2016. p. 103–13.
Sandoval, D., et al. “Glucagon in Islet and Metabolic Regulation.” Textbook of Diabetes Fifth Edition, 2016, pp. 103–13. Scopus, doi:10.1002/9781118924853.ch7.
Sandoval D, Tong J, D’Alessio D. Glucagon in Islet and Metabolic Regulation. Textbook of Diabetes Fifth Edition. 2016. p. 103–113.