Contemporary Contrast Media Dosing During Percutaneous Coronary Intervention in Patients With Preexisting Renal Impairment

Objectives. Contrast volume minimization can mitigate acute kidney injury (AKI) risk following percutaneous coronary intervention (PCI), but national data regarding contemporary contrast volume dosing patterns are lacking. The authors analyzed data from the National Cardiovascular Data Registry (NCDR) CathPCI registry to assess the prevalence and outcomes of renal function-based contrast dosing during PCI in patients with pre-existing renal impairment. Methods. The authors analyzed data from 463 753 patients with an eGFR ≤ 60 mL/min/1.73 m², and categorized patients based on contrast volume/eGFR: high (> 3), low (1–3), and ultra-low (< 1). eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine equation. The primary outcome was the occurrence of AKI. Outcomes were adjusted based on covariates derived from a validated AKI prediction model. Results. The majority (51.4%) of patients received high contrast volume. Compared with patients who received low contrast volume, patients with high contrast volume use had a significantly higher incidence of AKI (adjusted OR 1.36 [1.28 to 1.45]) and a higher stage of AKI (adjusted OR 1.90 [1.80 to 2.00]). The incidence of AKI was similar between low and ultra-low contrast volume use. The development of new need for dialysis was higher in patients who received high contrast volume (2.8%) compared with those who received low contrast volume (0.8%) and ultra-low contrast volume (0.8%) (P < .001). Conclusions. High contrast volume during PCI is associated with worse outcomes including AKI and new need for dialysis. Our study provides further support for the use of contrast volume less than 3 times the eGFR as a target to guide contrast dosing during PCI.

Duke Scholars

Author Daniel Wojdyla