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Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age.

Publication ,  Journal Article
Cherenack, EM; Brophy, TF; Max, MA; Graubard-Silebi, A; Nogueira, NF; Pan, Y; Westreich, D; Topper, EF; Konkle-Parker, D; Rana, A; Kassaye, SG ...
Published in: AIDS Behav
October 2025

Positive attitudes towards aging (ATA) are associated with better mental and physical health in the general population and with lower depressive symptoms among men living with HIV. Little is known about ATA among women of reproductive age living with HIV (WWH), who often experience premature aging, depression, and chronic pain. This study examined the association of ATA with HIV, physical functioning, and pain among women 19-45 years-of-age. From 2021 to 2022, survey data were collected at baseline from 143 WWH and 39 women without HIV (WWOH) across the southern United States; 94 WWH also completed a six-month follow-up visit. Baseline ATA was compared across HIV status. Among WWH, correlations between ATA, participant factors relevant in prior research (i.e., age, depression, illness), pain, and physical functioning were examined. Regressions examined the association of baseline ATA with physical functioning and pain across visits, including when controlling for potential confounders. Having one or more negative ATA was reported by an equal proportion of WWH (57%) and WWOH (58%). Among WWH, more positive ATA correlated with lower depressive symptoms, better physical functioning, and lower pain at baseline. Lower depressive symptoms correlated with better physical functioning and lower pain at baseline. In regressions, more positive ATA was associated with better physical functioning at baseline and follow-up. A weak association of ATA with pain at baseline was not significant at follow-up or after controlling for depression. Research is warranted to examine how combined interventions to improve ATA, depression, and pain can support well-being among reproductive-aged WWH.

Duke Scholars

Published In

AIDS Behav

DOI

EISSN

1573-3254

Publication Date

October 2025

Volume

29

Issue

10

Start / End Page

3012 / 3025

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Surveys and Questionnaires
  • Public Health
  • Pain
  • Middle Aged
  • Humans
  • HIV Infections
  • Female
  • Depression
 

Citation

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MLA
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Cherenack, E. M., Brophy, T. F., Max, M. A., Graubard-Silebi, A., Nogueira, N. F., Pan, Y., … Alcaide, M. L. (2025). Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age. AIDS Behav, 29(10), 3012–3025. https://doi.org/10.1007/s10461-025-04724-9
Cherenack, Emily M., Theodora F. Brophy, Margarita Avila Max, Alicia Graubard-Silebi, Nicholas F. Nogueira, Yue Pan, Daniel Westreich, et al. “Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age.AIDS Behav 29, no. 10 (October 2025): 3012–25. https://doi.org/10.1007/s10461-025-04724-9.
Cherenack EM, Brophy TF, Max MA, Graubard-Silebi A, Nogueira NF, Pan Y, et al. Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age. AIDS Behav. 2025 Oct;29(10):3012–25.
Cherenack, Emily M., et al. “Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age.AIDS Behav, vol. 29, no. 10, Oct. 2025, pp. 3012–25. Pubmed, doi:10.1007/s10461-025-04724-9.
Cherenack EM, Brophy TF, Max MA, Graubard-Silebi A, Nogueira NF, Pan Y, Westreich D, Topper EF, Konkle-Parker D, Rana A, Kassaye SG, Sheth AN, Jones DL, Alcaide ML. Attitudes Towards Aging, Depression, Physical Functioning, and Pain Among Women Living with HIV of Reproductive Age. AIDS Behav. 2025 Oct;29(10):3012–3025.
Journal cover image

Published In

AIDS Behav

DOI

EISSN

1573-3254

Publication Date

October 2025

Volume

29

Issue

10

Start / End Page

3012 / 3025

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Surveys and Questionnaires
  • Public Health
  • Pain
  • Middle Aged
  • Humans
  • HIV Infections
  • Female
  • Depression