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Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial.

Publication ,  Journal Article
Ke, YH; Yang Ong, BS; Jin, L; Sim, JXL; Chan, CH; Soh, CR; Wong, DJN; Liu, N; Sng, BL; Ting, DSW; Yeo, SQ; Ong, MEH; Abdullah, HR
Published in: NPJ Digit Med
July 21, 2025

Preoperative assessment is a critical but time-consuming component of perioperative care, often hindered by poor guideline adherence and high documentation burdens. This study evaluates the impact of PEACH (PErioperative AI CHatbot), an LLM-based clinical decision support system, on documentation efficiency, quality, user acceptance, and cost-effectiveness in preoperative consultations. PEACH did not significantly reduce overall documentation time in this randomized crossover trial involving resident physicians at Singapore General Hospital. However, subgroup analyses showed time savings for moderate-complexity patients (5.77 min, p = 0.010) and experienced physicians (4.6 min, p = 0.040). Evaluators preferred PEACH-assisted documentation in 57.1% of cases, with improved inclusion of issue lists (p = 0.05). Economic modeling projected annual institutional savings of SGD197,501 (USD146,297), with sensitivity analyses ranging from SGD 48,979 to 197,499 (USD36,280 to 146,295). These findings suggest that LLM-based tools like PEACH may enhance preoperative documentation efficiency and offer economic value.

Duke Scholars

Published In

NPJ Digit Med

DOI

EISSN

2398-6352

Publication Date

July 21, 2025

Volume

8

Issue

1

Start / End Page

462

Location

England

Related Subject Headings

  • 4203 Health services and systems
 

Citation

APA
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ICMJE
MLA
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Ke, Y. H., Yang Ong, B. S., Jin, L., Sim, J. X. L., Chan, C. H., Soh, C. R., … Abdullah, H. R. (2025). Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial. NPJ Digit Med, 8(1), 462. https://doi.org/10.1038/s41746-025-01858-x
Ke, Yu He, Bernard Soon Yang Ong, Liyuan Jin, Jacqueline Xiu Ling Sim, Chi Ho Chan, Chai Rick Soh, Danny Jon Nian Wong, et al. “Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial.NPJ Digit Med 8, no. 1 (July 21, 2025): 462. https://doi.org/10.1038/s41746-025-01858-x.
Ke YH, Yang Ong BS, Jin L, Sim JXL, Chan CH, Soh CR, et al. Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial. NPJ Digit Med. 2025 Jul 21;8(1):462.
Ke, Yu He, et al. “Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial.NPJ Digit Med, vol. 8, no. 1, July 2025, p. 462. Pubmed, doi:10.1038/s41746-025-01858-x.
Ke YH, Yang Ong BS, Jin L, Sim JXL, Chan CH, Soh CR, Wong DJN, Liu N, Sng BL, Ting DSW, Yeo SQ, Ong MEH, Abdullah HR. Clinical and economic impact of a large language model in perioperative medicine: a randomized crossover trial. NPJ Digit Med. 2025 Jul 21;8(1):462.

Published In

NPJ Digit Med

DOI

EISSN

2398-6352

Publication Date

July 21, 2025

Volume

8

Issue

1

Start / End Page

462

Location

England

Related Subject Headings

  • 4203 Health services and systems