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Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study.

Publication ,  Journal Article
Johnson, AJ; Sims, M; Okundolor, C; James, SA; Kirby, KA
Published in: Social science & medicine (1982)
October 2025

Optimal cardiovascular health (CVH) reduces cardiovascular disease risk. However, further research should clarify the role of psychosocial factors on CVH among African Americans. The current cross-sectional study sought to examine the relationship between discrimination, chronic stress, and CVH among African Americans in the Jackson Heart Study (n = 4737). The associations between discrimination (i.e., daily, lifetime, and discrimination burden), chronic stress, and achieving ideal CVH and CVH indicators (e.g., smoking, diet, blood pressure) were investigated using multinomial logistic regression analysis. Multivariable linear regression models also examined associations between discrimination, chronic stress, and CVH scores. Greater perceived daily discrimination was associated with 11 % lower odds of being in the ideal smoking category (never smoking or quit smoking >12 months ago), whereas greater chronic stress was associated with 5 % lower odds of being in this category. Greater perceived daily, lifetime, and burden of lifetime discrimination was associated with decreased odds of having an ideal BMI (<25.0) by 14 %, 22 %, and 16 %, respectively. Chronic stress modified these associations, slightly increasing odds of having an ideal BMI by 2 %, 3 %, and 8 % for perceived daily, lifetime, and burden of lifetime discrimination. Higher scores on perceived daily discrimination were associated with lower LS7 scores (β = -0.09, -16, -0.01) while higher lifetime discrimination was associated with higher LS7 scores. These complex findings support continued focus on research elucidating the underlying mechanisms linking psychosocial stress and CVH among African Americans.

Duke Scholars

Published In

Social science & medicine (1982)

DOI

EISSN

1873-5347

ISSN

0277-9536

Publication Date

October 2025

Volume

383

Start / End Page

118460

Related Subject Headings

  • White
  • Stress, Psychological
  • Racism
  • Public Health
  • Mississippi
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies
 

Citation

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Johnson, A. J., Sims, M., Okundolor, C., James, S. A., & Kirby, K. A. (2025). Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study. Social Science & Medicine (1982), 383, 118460. https://doi.org/10.1016/j.socscimed.2025.118460
Johnson, Amber J., Mario Sims, Chelsea Okundolor, Sherman A. James, and Katharine A. Kirby. “Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study.Social Science & Medicine (1982) 383 (October 2025): 118460. https://doi.org/10.1016/j.socscimed.2025.118460.
Johnson AJ, Sims M, Okundolor C, James SA, Kirby KA. Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study. Social science & medicine (1982). 2025 Oct;383:118460.
Johnson, Amber J., et al. “Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study.Social Science & Medicine (1982), vol. 383, Oct. 2025, p. 118460. Epmc, doi:10.1016/j.socscimed.2025.118460.
Johnson AJ, Sims M, Okundolor C, James SA, Kirby KA. Discrimination, chronic stress, and cardiovascular health among African American men and women in the Jackson Heart Study: A cross-sectional study. Social science & medicine (1982). 2025 Oct;383:118460.
Journal cover image

Published In

Social science & medicine (1982)

DOI

EISSN

1873-5347

ISSN

0277-9536

Publication Date

October 2025

Volume

383

Start / End Page

118460

Related Subject Headings

  • White
  • Stress, Psychological
  • Racism
  • Public Health
  • Mississippi
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies