A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.
Publication
, Journal Article
Crowell, C; Zhu, Z; Li, Y; Varela, ML; Ostrom, Q; Cimino, PJ; Patel, SH; Baker, SJ; Bettegowda, C; Noushmehr, H; Kleinman, CL; Canty, L ...
Published in: NPJ Precis Oncol
August 14, 2025
Diffuse hemispheric glioma H3 G34-mutant is primarily diagnosed in adolescents/young adults. While molecular diagnostics have improved, cellular mechanisms that drive tumor progression and therapy resistance are poorly understood. Combining previous published studies with findings from the 2024 NIH G34-mutant symposium aid in summarizing translational and clinical updates on disease development, cellular repair processes, and the immune microenvironment. This collective work is meant to outline opportunities for treatment and prolonged survival.
Duke Scholars
Published In
NPJ Precis Oncol
DOI
ISSN
2397-768X
Publication Date
August 14, 2025
Volume
9
Issue
1
Start / End Page
283
Location
England
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Crowell, C., Zhu, Z., Li, Y., Varela, M. L., Ostrom, Q., Cimino, P. J., … Jackson, S. (2025). A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon. NPJ Precis Oncol, 9(1), 283. https://doi.org/10.1038/s41698-025-01070-w
Crowell, Cameron, Ziwen Zhu, Yingxiang Li, Maria L. Varela, Quinn Ostrom, Patrick J. Cimino, Sohil H. Patel, et al. “A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.” NPJ Precis Oncol 9, no. 1 (August 14, 2025): 283. https://doi.org/10.1038/s41698-025-01070-w.
Crowell C, Zhu Z, Li Y, Varela ML, Ostrom Q, Cimino PJ, et al. A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon. NPJ Precis Oncol. 2025 Aug 14;9(1):283.
Crowell, Cameron, et al. “A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.” NPJ Precis Oncol, vol. 9, no. 1, Aug. 2025, p. 283. Pubmed, doi:10.1038/s41698-025-01070-w.
Crowell C, Zhu Z, Li Y, Varela ML, Ostrom Q, Cimino PJ, Patel SH, Baker SJ, Bettegowda C, Noushmehr H, Kleinman CL, Canty L, Cruzeiro GAV, Nellan A, Becher O, Davidson TB, Hambardzumyan D, Green A, Thorne R, Wilson K, Theeler B, Gregory J, Mathen P, Biassou N, McThenia S, Erker C, Galvin R, Soldatos A, Lowenstein PR, Castro MG, Jackson S. A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon. NPJ Precis Oncol. 2025 Aug 14;9(1):283.
Published In
NPJ Precis Oncol
DOI
ISSN
2397-768X
Publication Date
August 14, 2025
Volume
9
Issue
1
Start / End Page
283
Location
England
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3204 Immunology