Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib.
Publication
, Journal Article
Patel, PN; Hunt, R; Pettigrew, ZJ; Shirley, JB; Vogel, TP; de Guzman, MM
Published in: Pediatr Dermatol
March 2021
Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome is a rare autoinflammatory disorder. Cutaneous manifestations of CANDLE syndrome include characteristic recurring violaceous annular plaques comprised of an immature dermal mononuclear cell infiltrate. In CANDLE syndrome, deleterious genetic mutations inhibit proteasome-immunoproteasome function, resulting in cellular accumulation of ubiquitinated waste proteins that activate type I interferon signaling to drive inflammation. We describe a report of successful treatment of a 12-year-old girl with CANDLE syndrome with tofacitinib.
Duke Scholars
Published In
Pediatr Dermatol
DOI
EISSN
1525-1470
Publication Date
March 2021
Volume
38
Issue
2
Start / End Page
528 / 529
Location
United States
Related Subject Headings
- Sweet Syndrome
- Skin Diseases
- Pyrimidines
- Piperidines
- Lipodystrophy
- Immunologic Deficiency Syndromes
- Humans
- Fever
- Female
- Dermatology & Venereal Diseases
Citation
APA
Chicago
ICMJE
MLA
NLM
Patel, P. N., Hunt, R., Pettigrew, Z. J., Shirley, J. B., Vogel, T. P., & de Guzman, M. M. (2021). Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib. Pediatr Dermatol, 38(2), 528–529. https://doi.org/10.1111/pde.14517
Patel, Pooja N., Raegan Hunt, Zachary J. Pettigrew, Joel Brian Shirley, Tiphanie P. Vogel, and Marietta M. de Guzman. “Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib.” Pediatr Dermatol 38, no. 2 (March 2021): 528–29. https://doi.org/10.1111/pde.14517.
Patel PN, Hunt R, Pettigrew ZJ, Shirley JB, Vogel TP, de Guzman MM. Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib. Pediatr Dermatol. 2021 Mar;38(2):528–9.
Patel, Pooja N., et al. “Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib.” Pediatr Dermatol, vol. 38, no. 2, Mar. 2021, pp. 528–29. Pubmed, doi:10.1111/pde.14517.
Patel PN, Hunt R, Pettigrew ZJ, Shirley JB, Vogel TP, de Guzman MM. Successful treatment of chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome with tofacitinib. Pediatr Dermatol. 2021 Mar;38(2):528–529.
Published In
Pediatr Dermatol
DOI
EISSN
1525-1470
Publication Date
March 2021
Volume
38
Issue
2
Start / End Page
528 / 529
Location
United States
Related Subject Headings
- Sweet Syndrome
- Skin Diseases
- Pyrimidines
- Piperidines
- Lipodystrophy
- Immunologic Deficiency Syndromes
- Humans
- Fever
- Female
- Dermatology & Venereal Diseases