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What Is Fair? Defining Fairness in Machine Learning for Health.

Publication ,  Journal Article
Gao, J; Chou, B; McCaw, ZR; Thurston, H; Varghese, P; Hong, C; Gronsbell, J
Published in: Stat Med
September 2025

Ensuring that machine-learning (ML) models are safe, effective, and equitable across all patients is critical for clinical decision-making and for preventing the amplification of existing health disparities. In this work, we examine how fairness is conceptualized in ML for health, including why ML models may lead to unfair decisions and how fairness has been measured in diverse real-world applications. We review commonly used fairness notions within group, individual, and causal-based frameworks. We also discuss the outlook for future research and highlight opportunities and challenges in operationalizing fairness in health-focused applications.

Duke Scholars

Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

September 2025

Volume

44

Issue

20-22

Start / End Page

e70234

Location

England

Related Subject Headings

  • Statistics & Probability
  • Social Justice
  • Machine Learning
  • Humans
  • Clinical Decision-Making
  • 4905 Statistics
  • 4202 Epidemiology
  • 1117 Public Health and Health Services
  • 0104 Statistics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, J., Chou, B., McCaw, Z. R., Thurston, H., Varghese, P., Hong, C., & Gronsbell, J. (2025). What Is Fair? Defining Fairness in Machine Learning for Health. Stat Med, 44(20–22), e70234. https://doi.org/10.1002/sim.70234
Gao, Jianhui, Benson Chou, Zachary R. McCaw, Hilary Thurston, Paul Varghese, Chuan Hong, and Jessica Gronsbell. “What Is Fair? Defining Fairness in Machine Learning for Health.Stat Med 44, no. 20–22 (September 2025): e70234. https://doi.org/10.1002/sim.70234.
Gao J, Chou B, McCaw ZR, Thurston H, Varghese P, Hong C, et al. What Is Fair? Defining Fairness in Machine Learning for Health. Stat Med. 2025 Sep;44(20–22):e70234.
Gao, Jianhui, et al. “What Is Fair? Defining Fairness in Machine Learning for Health.Stat Med, vol. 44, no. 20–22, Sept. 2025, p. e70234. Pubmed, doi:10.1002/sim.70234.
Gao J, Chou B, McCaw ZR, Thurston H, Varghese P, Hong C, Gronsbell J. What Is Fair? Defining Fairness in Machine Learning for Health. Stat Med. 2025 Sep;44(20–22):e70234.
Journal cover image

Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

September 2025

Volume

44

Issue

20-22

Start / End Page

e70234

Location

England

Related Subject Headings

  • Statistics & Probability
  • Social Justice
  • Machine Learning
  • Humans
  • Clinical Decision-Making
  • 4905 Statistics
  • 4202 Epidemiology
  • 1117 Public Health and Health Services
  • 0104 Statistics