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Supplementary Figure S6 from Phase 2, Open-Label, Multicenter Study of Nelitolimod in Combination with Pembrolizumab in Anti–PD-1 Treatment-Naïve Advanced Melanoma

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Ribas, A; Milhem, MM; Hoimes, CJ; Amin, A; Lao, CD; Conry, RM; Hunt, JP; Daniels, GA; Almubarak, M; Shaheen, M; Medina, T; Barve, M; Abdi, E ...
October 1, 2025

<p>Figure S6 shows transcriptomic data from paired tumor biopsies collected at baseline and on therapy from patients treated with nelitolimod 2 mg plus pembrolizumab 200 mg. The figure displays consistent and durable increases in the expression of gene signatures representing immune cell density and upregulation of functional signatures.</p>

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Publication Date

October 1, 2025
 

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Ribas, A., Milhem, M. M., Hoimes, C. J., Amin, A., Lao, C. D., Conry, R. M., … Long, G. V. (2025). Supplementary Figure S6 from Phase 2, Open-Label, Multicenter Study of Nelitolimod in Combination with Pembrolizumab in Anti–PD-1 Treatment-Naïve Advanced Melanoma. https://doi.org/10.1158/1078-0432.30255659
Ribas, Antoni, Mohammed M. Milhem, Christopher J. Hoimes, Asim Amin, Christopher D. Lao, Robert M. Conry, Jason P. Hunt, et al. “Supplementary Figure S6 from Phase 2, Open-Label, Multicenter Study of Nelitolimod in Combination with Pembrolizumab in Anti–PD-1 Treatment-Naïve Advanced Melanoma,” October 1, 2025. https://doi.org/10.1158/1078-0432.30255659.
Ribas A, Milhem MM, Hoimes CJ, Amin A, Lao CD, Conry RM, Hunt JP, Daniels GA, Almubarak M, Shaheen M, Medina T, Barve M, Bishnoi S, Abdi E, Chisamore MJ, Guiducci C, Gomez-Romo J, Candia A, Gamelin E, Coffman RL, Janssen RS, Long GV. Supplementary Figure S6 from Phase 2, Open-Label, Multicenter Study of Nelitolimod in Combination with Pembrolizumab in Anti–PD-1 Treatment-Naïve Advanced Melanoma. 2025.

DOI

Publication Date

October 1, 2025