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Validation of a MIND diet screener in older adults.

Publication ,  Journal Article
Dempsey, DA; Agarwal, P; Fernandez, S; Brosch, JR; Gao, S; Clark, DO; Unverzagt, FW; Apostolova, LG; Clark, DG; Farlow, MR; Mathew, S; Wang, S ...
Published in: Alzheimers Dement
October 2025

INTRODUCTION: Higher adherence to the Mediterranean-DASH (Dietary Approaches to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) diet has been associated with reduced Alzheimer's disease (AD) risk. This study assessed the validity of a brief 15-item MIND diet screener compared to a comprehensive food frequency questionnaire (FFQ). METHODS: The validity of an adapted MIND diet screener relative to the VioScreen FFQ was evaluated in 92 older adults from the Indiana Alzheimer's Disease Research Center (IADRC). Correlation coefficients and tertile-based classification statistics were used, and FFQ nutrient profiles were examined across screener-based MIND diet tertiles. RESULTS: MIND diet scores from the screener showed strong positive correlation (r = 0.71, ρ = 0.70, p < 0.001) and comparable ranking ability (63% correctly classified, 1% grossly misclassified, kw = 0.67) compared to those from the FFQ, as well as significant associations with nutrient profiles. CONCLUSION: The MIND diet screener is an acceptable, time-efficient tool for estimating MIND diet scores in older adults. HIGHLIGHTS: The MIND diet screener effectively differentiated participants by diet quality. Agreement between instrument scores was consistent across diagnostic groups. Reliability of the screener over approximately 1 year was comparable to the FFQ. The MIND diet screener is an acceptable tool for use in time-constrained settings. Future studies should confirm validity using objective biomarkers.

Duke Scholars

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

October 2025

Volume

21

Issue

10

Start / End Page

e70766

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Reproducibility of Results
  • Male
  • Indiana
  • Humans
  • Geriatrics
  • Female
  • Dietary Approaches To Stop Hypertension
  • Diet, Mediterranean
  • Alzheimer Disease
 

Citation

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Dempsey, D. A., Agarwal, P., Fernandez, S., Brosch, J. R., Gao, S., Clark, D. O., … Alzheimer Gut Microbiome Project Consortium. (2025). Validation of a MIND diet screener in older adults. Alzheimers Dement, 21(10), e70766. https://doi.org/10.1002/alz.70766
Dempsey, Desarae A., Puja Agarwal, Shane Fernandez, Jared R. Brosch, Sujuan Gao, Daniel O. Clark, Frederick W. Unverzagt, et al. “Validation of a MIND diet screener in older adults.Alzheimers Dement 21, no. 10 (October 2025): e70766. https://doi.org/10.1002/alz.70766.
Dempsey DA, Agarwal P, Fernandez S, Brosch JR, Gao S, Clark DO, et al. Validation of a MIND diet screener in older adults. Alzheimers Dement. 2025 Oct;21(10):e70766.
Dempsey, Desarae A., et al. “Validation of a MIND diet screener in older adults.Alzheimers Dement, vol. 21, no. 10, Oct. 2025, p. e70766. Pubmed, doi:10.1002/alz.70766.
Dempsey DA, Agarwal P, Fernandez S, Brosch JR, Gao S, Clark DO, Unverzagt FW, Apostolova LG, Clark DG, Farlow MR, Mathew S, Wang S, Quirke M, Graham-Dotson Y, Blach C, Schimmel L, Kaddurah-Daouk R, Saykin AJ, Risacher SL, Alzheimer Gut Microbiome Project Consortium. Validation of a MIND diet screener in older adults. Alzheimers Dement. 2025 Oct;21(10):e70766.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

October 2025

Volume

21

Issue

10

Start / End Page

e70766

Location

United States

Related Subject Headings

  • Surveys and Questionnaires
  • Reproducibility of Results
  • Male
  • Indiana
  • Humans
  • Geriatrics
  • Female
  • Dietary Approaches To Stop Hypertension
  • Diet, Mediterranean
  • Alzheimer Disease