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Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial

Publication ,  Journal Article
Zhang, J; Castelli, G; Shen, A; Li, J; Kawi, J; Wu, H; Christo, P; Campbell, CM; Thrul, J; Johnson, CM; Lukkahatai, N
Published in: Sleep Medicine X
December 15, 2025

Introduction: Insomnia is highly prevalent among older adults with chronic low back pain (cLBP), contributing to a cycle of heightened pain sensitivity, impaired physical function, and reduced quality of life. Auricular Point Acupressure (APA), a nonpharmacologic intervention for pain, has shown emerging evidence of improving sleep. We compared the effectiveness of targeted APA (T-APA) versus non-targeted APA (NT-APA) on insomnia in older adults with cLBP. Methods: This secondary analysis used data from a parent RCT, including 99 adults aged 60 or older with cLBP and clinical insomnia (Insomnia Severity Index [ISI]>7). Participants received four weeks of T-APA or NT-APA. Sleep outcomes (ISI, PROMIS-29 sleep disturbance) and pain outcomes (intensity, interference) were assessed at baseline and post-intervention, with pain examined as a mediator of sleep change. Results: The T-APA (n = 45) and NT-APA (n = 54) groups had similar baseline characteristics. Both groups showed significant reductions in sleep disturbance, pain interference, and pain intensity (p < 0.05). However, only the NT-APA group demonstrated significant improvement in ISI scores (p < 0.001, d = 0.50). No significant mediation effect of pain on sleep outcomes was found. Conclusions: APA may be an effective nonpharmacologic approach for improving sleep among older adults with cLBP. Unexpectedly, NT-APA showed greater improvements in insomnia compared to T-APA, suggesting mechanisms beyond traditional somatotopic theory. Further research is warranted to confirm these findings and explore the potential of point-specific versus non-specific APA protocols in treating insomnia. Trial ID: NCT03589703 (registration date: May 22, 2018). URL: https://clinicaltrials.gov/ct2/show/record/NCT03589703.

Duke Scholars

Published In

Sleep Medicine X

DOI

EISSN

2590-1427

Publication Date

December 15, 2025

Volume

10

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Zhang, J., Castelli, G., Shen, A., Li, J., Kawi, J., Wu, H., … Lukkahatai, N. (2025). Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial. Sleep Medicine X, 10. https://doi.org/10.1016/j.sleepx.2025.100158
Zhang, J., G. Castelli, A. Shen, J. Li, J. Kawi, H. Wu, P. Christo, et al. “Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial.” Sleep Medicine X 10 (December 15, 2025). https://doi.org/10.1016/j.sleepx.2025.100158.
Zhang J, Castelli G, Shen A, Li J, Kawi J, Wu H, et al. Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial. Sleep Medicine X. 2025 Dec 15;10.
Zhang, J., et al. “Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial.” Sleep Medicine X, vol. 10, Dec. 2025. Scopus, doi:10.1016/j.sleepx.2025.100158.
Zhang J, Castelli G, Shen A, Li J, Kawi J, Wu H, Christo P, Campbell CM, Thrul J, Johnson CM, Lukkahatai N. Effectiveness of acupressure at different ear acupoints on Insomnia: A secondary analysis of a randomized controlled trial. Sleep Medicine X. 2025 Dec 15;10.
Journal cover image

Published In

Sleep Medicine X

DOI

EISSN

2590-1427

Publication Date

December 15, 2025

Volume

10

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences