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Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey

Publication ,  Journal Article
Ling, C; Zhao, X; Lu, J; Deng, C; Zheng, C; Wang, J; Chowdhury, T; Li, Y; Cui, H; Zhang, X; Zhao, T; Panalkar, A; Mehta, D; Pasquali, S ...
Published in: ACM Computing Surveys
October 6, 2025

Large language models (LLMs) have significantly advanced the field of natural language processing (NLP), providing a highly useful, task-agnostic foundation for a wide range of applications. However, directly applying LLMs to solve sophisticated problems in specific domains meets many hurdles, caused by the heterogeneity of domain data, the sophistication of domain knowledge, the uniqueness of domain objectives, and the diversity of the constraints (e.g., various social norms, cultural conformity, religious beliefs, and ethical standards in the domain applications). Domain specification techniques are key to making large language models disruptive in many applications. Specifically, to solve these hurdles, there has been a notable increase in research and practices conducted in recent years on the domain specialization of LLMs. This emerging field of study, with its substantial potential for impact, necessitates a comprehensive and systematic review to summarize better and guide ongoing work in this area. In this article, we present a comprehensive survey on domain specification techniques for large language models, an emerging direction critical for large language model applications. First, we propose a systematic taxonomy that categorizes the LLM domain-specialization techniques based on the accessibility to LLMs and summarizes the framework for all the subcategories as well as their relations and differences to each other. Second, we present an extensive taxonomy of critical application domains that can benefit dramatically from specialized LLMs, discussing their practical significance and open challenges. Last, we offer our insights into the current research status and future trends in this area.

Duke Scholars

Published In

ACM Computing Surveys

DOI

EISSN

1557-7341

ISSN

0360-0300

Publication Date

October 6, 2025

Volume

58

Issue

3

Related Subject Headings

  • Information Systems
  • 46 Information and computing sciences
  • 08 Information and Computing Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Ling, C., Zhao, X., Lu, J., Deng, C., Zheng, C., Wang, J., … Zhao, L. (2025). Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey. ACM Computing Surveys, 58(3). https://doi.org/10.1145/3764579
Ling, C., X. Zhao, J. Lu, C. Deng, C. Zheng, J. Wang, T. Chowdhury, et al. “Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey.” ACM Computing Surveys 58, no. 3 (October 6, 2025). https://doi.org/10.1145/3764579.
Ling C, Zhao X, Lu J, Deng C, Zheng C, Wang J, et al. Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey. ACM Computing Surveys. 2025 Oct 6;58(3).
Ling, C., et al. “Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey.” ACM Computing Surveys, vol. 58, no. 3, Oct. 2025. Scopus, doi:10.1145/3764579.
Ling C, Zhao X, Lu J, Deng C, Zheng C, Wang J, Chowdhury T, Li Y, Cui H, Zhang X, Zhao T, Panalkar A, Mehta D, Pasquali S, Cheng W, Wang H, Liu Y, Chen Z, Chen H, White C, Gu Q, Pei J, Yang C, Zhao L. Domain Specialization as the Key to Make Large Language Models Disruptive: A Comprehensive Survey. ACM Computing Surveys. 2025 Oct 6;58(3).

Published In

ACM Computing Surveys

DOI

EISSN

1557-7341

ISSN

0360-0300

Publication Date

October 6, 2025

Volume

58

Issue

3

Related Subject Headings

  • Information Systems
  • 46 Information and computing sciences
  • 08 Information and Computing Sciences