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Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.

Publication ,  Journal Article
Drew, RH; Turner, NA; Keil, E; Seidelman, J
Published in: Infect Control Hosp Epidemiol
February 2026

In a propensity-matched cohort of adult cardiac or neurosurgical procedures (n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (-0.6%, 95% CI-2.3 to 1.1; p = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation.

Duke Scholars

Published In

Infect Control Hosp Epidemiol

DOI

EISSN

1559-6834

Publication Date

February 2026

Volume

47

Issue

2

Start / End Page

195 / 198

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Retrospective Studies
  • Propensity Score
  • Neurosurgical Procedures
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Humans
  • Female
  • Epidemiology
 

Citation

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ICMJE
MLA
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Drew, R. H., Turner, N. A., Keil, E., & Seidelman, J. (2026). Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery. Infect Control Hosp Epidemiol, 47(2), 195–198. https://doi.org/10.1017/ice.2025.10365
Drew, Richard H., Nicholas A. Turner, Elizabeth Keil, and Jessica Seidelman. “Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.Infect Control Hosp Epidemiol 47, no. 2 (February 2026): 195–98. https://doi.org/10.1017/ice.2025.10365.
Drew, Richard H., et al. “Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery.Infect Control Hosp Epidemiol, vol. 47, no. 2, Feb. 2026, pp. 195–98. Pubmed, doi:10.1017/ice.2025.10365.
Journal cover image

Published In

Infect Control Hosp Epidemiol

DOI

EISSN

1559-6834

Publication Date

February 2026

Volume

47

Issue

2

Start / End Page

195 / 198

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Retrospective Studies
  • Propensity Score
  • Neurosurgical Procedures
  • Middle Aged
  • Male
  • Infusions, Intravenous
  • Humans
  • Female
  • Epidemiology