Encyclopedia of Biostatistics Armitage Enc Biostats 2e
Minimum Therapeutically Effective Dose
Publication
, Chapter
Liu, JP; Chow, SC
January 1, 2006
The concept and definitions of minimum therapeutic effective dose (MTED) and therapeutic window of a drug are presented. Design and analysis for estimating MTED are overviewed. Design issues such as inclusion of a placebo concurrent control, selection of dose levels, and sample size determination are addressed. Statistical analyses such as the application of analysis of variance and model-based approach to estimating MTED are summarized. Discussion on internal validity vs. external evidence is also provided.
Duke Scholars
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, J. P., & Chow, S. C. (2006). Minimum Therapeutically Effective Dose. In Encyclopedia of Biostatistics Armitage Enc Biostats 2e (pp. 1–2). https://doi.org/10.1002/0470011815.b2a06018
Liu, J. P., and S. C. Chow. “Minimum Therapeutically Effective Dose.” In Encyclopedia of Biostatistics Armitage Enc Biostats 2e, 1–2, 2006. https://doi.org/10.1002/0470011815.b2a06018.
Liu JP, Chow SC. Minimum Therapeutically Effective Dose. In: Encyclopedia of Biostatistics Armitage Enc Biostats 2e. 2006. p. 1–2.
Liu, J. P., and S. C. Chow. “Minimum Therapeutically Effective Dose.” Encyclopedia of Biostatistics Armitage Enc Biostats 2e, 2006, pp. 1–2. Scopus, doi:10.1002/0470011815.b2a06018.
Liu JP, Chow SC. Minimum Therapeutically Effective Dose. Encyclopedia of Biostatistics Armitage Enc Biostats 2e. 2006. p. 1–2.