Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.
Publication
, Journal Article
De Bie, FR; Zhang, CJ; Rent, SM; Russ, JB; Ig-Izevbekhai, K; Antiel, RM
Published in: Children (Basel)
December 30, 2025
In this narrative review, we examine current neurological and neurodevelopmental outcomes associated with extreme prematurity, specifically in infants born between 22 and 24 weeks of gestational age. In addition, we explore the scientific and clinical rationale for the development of artificial womb technology and provide an overview of the current state of the art in preclinical models. For each model, we review and analyze the neurological outcomes, including structural, developmental, and functional outcomes, evaluating their limitations in anticipation of imminent clinical translation.
Duke Scholars
Published In
Children (Basel)
DOI
ISSN
2227-9067
Publication Date
December 30, 2025
Volume
13
Issue
1
Location
Switzerland
Related Subject Headings
- 4206 Public health
- 3213 Paediatrics
Citation
APA
Chicago
ICMJE
MLA
NLM
De Bie, F. R., Zhang, C. J., Rent, S. M., Russ, J. B., Ig-Izevbekhai, K., & Antiel, R. M. (2025). Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children (Basel), 13(1). https://doi.org/10.3390/children13010047
De Bie, Felix R., Chelsea J. Zhang, Sharla M. Rent, Jeffrey B. Russ, Kevin Ig-Izevbekhai, and Ryan M. Antiel. “Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.” Children (Basel) 13, no. 1 (December 30, 2025). https://doi.org/10.3390/children13010047.
De Bie FR, Zhang CJ, Rent SM, Russ JB, Ig-Izevbekhai K, Antiel RM. Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children (Basel). 2025 Dec 30;13(1).
De Bie, Felix R., et al. “Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.” Children (Basel), vol. 13, no. 1, Dec. 2025. Pubmed, doi:10.3390/children13010047.
De Bie FR, Zhang CJ, Rent SM, Russ JB, Ig-Izevbekhai K, Antiel RM. Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children (Basel). 2025 Dec 30;13(1).
Published In
Children (Basel)
DOI
ISSN
2227-9067
Publication Date
December 30, 2025
Volume
13
Issue
1
Location
Switzerland
Related Subject Headings
- 4206 Public health
- 3213 Paediatrics