Scholars@Duke

Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes

Publication ,  Journal Article
De Bie, FR; Zhang, CJ; Rent, SM; Russ, JB; Ig-Izevbekhai, K; Antiel, RM
Published in: Children
December 30, 2025
Published version (DOI) Publisher Link

In this narrative review, we examine current neurological and neurodevelopmental outcomes associated with extreme prematurity, specifically in infants born between 22 and 24 weeks of gestational age. In addition, we explore the scientific and clinical rationale for the development of artificial womb technology and provide an overview of the current state of the art in preclinical models. For each model, we review and analyze the neurological outcomes, including structural, developmental, and functional outcomes, evaluating their limitations in anticipation of imminent clinical translation.

Duke Scholars

Sharla Marie Rent
Author Sharla Marie Rent Pediatrics, Neonatology
Felix De bie
Author Felix De bie  

Published In

Children

DOI

10.3390/children13010047

EISSN

2227-9067

Publication Date

December 30, 2025

Volume

13

Issue

1

Start / End Page

47 / 47

Publisher

MDPI AG

Related Subject Headings

  • 4206 Public health
  • 3213 Paediatrics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
De Bie, F. R., Zhang, C. J., Rent, S. M., Russ, J. B., Ig-Izevbekhai, K., & Antiel, R. M. (2025). Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children, 13(1), 47–47. https://doi.org/10.3390/children13010047
De Bie, Felix R., Chelsea J. Zhang, Sharla M. Rent, Jeffrey B. Russ, Kevin Ig-Izevbekhai, and Ryan M. Antiel. “Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.” Children 13, no. 1 (December 30, 2025): 47–47. https://doi.org/10.3390/children13010047.
De Bie FR, Zhang CJ, Rent SM, Russ JB, Ig-Izevbekhai K, Antiel RM. Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children. 2025 Dec 30;13(1):47–47.
De Bie, Felix R., et al. “Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.” Children, vol. 13, no. 1, MDPI AG, Dec. 2025, pp. 47–47. Crossref, doi:10.3390/children13010047.
De Bie FR, Zhang CJ, Rent SM, Russ JB, Ig-Izevbekhai K, Antiel RM. Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes. Children. MDPI AG; 2025 Dec 30;13(1):47–47.

Published In

Children

DOI

10.3390/children13010047

EISSN

2227-9067

Publication Date

December 30, 2025

Volume

13

Issue

1

Start / End Page

47 / 47

Publisher

MDPI AG

Related Subject Headings

  • 4206 Public health
  • 3213 Paediatrics