Deprotonative C-H Zincation for Carbon-Carbon Bond Formation
This article focuses on the recent developments of deprotonative C-H zincation approaches for carbon-carbon bond formation as a useful strategy of C-H functionalization. Key to the success of this strategy is the development of different zincate bases for regioselective C-H zincation and subsequent coupling reactions of the generated organozinc intermediates with various partners. Herein presented are recent examples using deprotonative C-H zincation strategy for diverse carbon functionalization of Csp[[sup]]3[[/sup]]-H, Csp[[sup]]2[[/sup]]-H, and Csp-H bonds, including the installation of alkyl, alkenyl, alkynyl, aryl, and acyl groups, as well as zincation-mediated multifunctionalization reactions in providing step-efficient synthetic strategies.
