The Inverse Radius for Detection of Patients with Cardiac Dyssynchrony
Cardiac dyssynchrony, particularly in patients with Left Bundle Branch Block (LBBB), poses significant challenges in clinical diagnostics. This study investigates the curvature of the interventricular septum (IVS) throughout the cardiac cycle, as a potential biomarker for detecting cardiac dyssynchrony in patients. Data from 28 subjects into three groups of which 14 subjects with no diagnosed cardiac abnormalities (Normal), and 14 dyssynchrony patients undergoing CRT treatment, with active external pacing (On), and without active pacing (Off). At all temporal points the IVS contour was fitted to a circle using the Levenberg-Marquardt algorithm, and the radius extracted and inversed. The inverse radius decreased significantly depending on cardiac health with the Normal, On, and Off groups being 0.43 ± 0.16, 0.49 ± 0.10, and 0.53 ± 0.15 respectfully. Findings suggest that the inverse radius could serve as a biomarker for identifying cardiac dyssynchrony in LBBB patients, potentially guiding therapeutic decisions and improving patient outcomes.
