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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

Publication ,  Journal Article
Voight, BF; Scott, LJ; Steinthorsdottir, V; Morris, AP; Dina, C; Welch, RP; Zeggini, E; Huth, C; Aulchenko, YS; Thorleifsson, G; McCulloch, LJ ...
Published in: Nature genetics
July 2010

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P<5x10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.

Duke Scholars

Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

July 2010

Volume

42

Issue

7

Start / End Page

579 / 589

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Mitogen-Activated Protein Kinase Phosphatases
  • Meta-Analysis as Topic
  • KCNQ1 Potassium Channel
  • Humans
  • Hepatocyte Nuclear Factor 1-alpha
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Predisposition to Disease
  • Genetic Heterogeneity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Voight, B. F., Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., … GIANT Consortium. (2010). Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics, 42(7), 579–589. https://doi.org/10.1038/ng.609
Voight, Benjamin F., Laura J. Scott, Valgerdur Steinthorsdottir, Andrew P. Morris, Christian Dina, Ryan P. Welch, Eleftheria Zeggini, et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Nature Genetics 42, no. 7 (July 2010): 579–89. https://doi.org/10.1038/ng.609.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature genetics. 2010 Jul;42(7):579–89.
Voight, Benjamin F., et al. “Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Nature Genetics, vol. 42, no. 7, July 2010, pp. 579–89. Epmc, doi:10.1038/ng.609.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney ASF, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PRV, Jørgensen T, Kao WHL, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JRB, Petersen A-K, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CNA, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann H-E, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, MAGIC investigators, GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature genetics. 2010 Jul;42(7):579–589.

Published In

Nature genetics

DOI

EISSN

1546-1718

ISSN

1061-4036

Publication Date

July 2010

Volume

42

Issue

7

Start / End Page

579 / 589

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Mitogen-Activated Protein Kinase Phosphatases
  • Meta-Analysis as Topic
  • KCNQ1 Potassium Channel
  • Humans
  • Hepatocyte Nuclear Factor 1-alpha
  • Genome-Wide Association Study
  • Genome, Human
  • Genetic Predisposition to Disease
  • Genetic Heterogeneity