Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.
Publication
, Journal Article
Schlegel, PG; Chao, NJ
Published in: Leuk Lymphoma
September 1996
Graft-versus-host disease (GVHD) represents the major barrier to successful allogeneic bone marrow transplantation. Positive and negative selection studies have unequivocally demonstrated that donor T cells are responsible for the induction phase of GVHD. Inhibition of the early steps of T cell antigen recognition leading to graft-versus-host disease has become an area of intense investigation. Peptides with high binding affinity for class II MHC molecules have been shown to compete for the single class II binding site and to inhibit T cell proliferative responses in vitro. Recent work has extended this approach to the prevention of murine GVHD in vivo.
Duke Scholars
Published In
Leuk Lymphoma
DOI
ISSN
1042-8194
Publication Date
September 1996
Volume
23
Issue
1-2
Start / End Page
11 / 16
Location
United States
Related Subject Headings
- T-Lymphocytes
- Peptides
- Molecular Sequence Data
- Mice
- Immunology
- Humans
- Histocompatibility Antigens Class II
- Graft vs Host Disease
- Bone Marrow Transplantation
- Antigen-Antibody Reactions
Citation
APA
Chicago
ICMJE
MLA
NLM
Schlegel, P. G., & Chao, N. J. (1996). Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leuk Lymphoma, 23(1–2), 11–16. https://doi.org/10.3109/10428199609054796
Schlegel, P. G., and N. J. Chao. “Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.” Leuk Lymphoma 23, no. 1–2 (September 1996): 11–16. https://doi.org/10.3109/10428199609054796.
Schlegel PG, Chao NJ. Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leuk Lymphoma. 1996 Sep;23(1–2):11–6.
Schlegel, P. G., and N. J. Chao. “Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.” Leuk Lymphoma, vol. 23, no. 1–2, Sept. 1996, pp. 11–16. Pubmed, doi:10.3109/10428199609054796.
Schlegel PG, Chao NJ. Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leuk Lymphoma. 1996 Sep;23(1–2):11–16.
Published In
Leuk Lymphoma
DOI
ISSN
1042-8194
Publication Date
September 1996
Volume
23
Issue
1-2
Start / End Page
11 / 16
Location
United States
Related Subject Headings
- T-Lymphocytes
- Peptides
- Molecular Sequence Data
- Mice
- Immunology
- Humans
- Histocompatibility Antigens Class II
- Graft vs Host Disease
- Bone Marrow Transplantation
- Antigen-Antibody Reactions