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Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.

Publication ,  Journal Article
Schlegel, PG; Chao, NJ
Published in: Leuk Lymphoma
September 1996

Graft-versus-host disease (GVHD) represents the major barrier to successful allogeneic bone marrow transplantation. Positive and negative selection studies have unequivocally demonstrated that donor T cells are responsible for the induction phase of GVHD. Inhibition of the early steps of T cell antigen recognition leading to graft-versus-host disease has become an area of intense investigation. Peptides with high binding affinity for class II MHC molecules have been shown to compete for the single class II binding site and to inhibit T cell proliferative responses in vitro. Recent work has extended this approach to the prevention of murine GVHD in vivo.

Duke Scholars

Published In

Leuk Lymphoma

DOI

ISSN

1042-8194

Publication Date

September 1996

Volume

23

Issue

1-2

Start / End Page

11 / 16

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Peptides
  • Molecular Sequence Data
  • Mice
  • Immunology
  • Humans
  • Histocompatibility Antigens Class II
  • Graft vs Host Disease
  • Bone Marrow Transplantation
  • Antigen-Antibody Reactions
 

Citation

APA
Chicago
ICMJE
MLA
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Schlegel, P. G., & Chao, N. J. (1996). Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leuk Lymphoma, 23(1–2), 11–16. https://doi.org/10.3109/10428199609054796
Schlegel, P. G., and N. J. Chao. “Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.Leuk Lymphoma 23, no. 1–2 (September 1996): 11–16. https://doi.org/10.3109/10428199609054796.
Schlegel, P. G., and N. J. Chao. “Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease.Leuk Lymphoma, vol. 23, no. 1–2, Sept. 1996, pp. 11–16. Pubmed, doi:10.3109/10428199609054796.
Journal cover image

Published In

Leuk Lymphoma

DOI

ISSN

1042-8194

Publication Date

September 1996

Volume

23

Issue

1-2

Start / End Page

11 / 16

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Peptides
  • Molecular Sequence Data
  • Mice
  • Immunology
  • Humans
  • Histocompatibility Antigens Class II
  • Graft vs Host Disease
  • Bone Marrow Transplantation
  • Antigen-Antibody Reactions