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Polymyositis as a manifestation of chronic graft-versus-host disease.

Publication ,  Journal Article
Parker, P; Chao, NJ; Ben-Ezra, J; Slatkin, N; Openshaw, H; Niland, JC; Linker, CA; Greffe, BS; Kashyap, A; Molina, A; Nademanee, A; Planas, I ...
Published in: Medicine (Baltimore)
September 1996

A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.

Duke Scholars

Published In

Medicine (Baltimore)

DOI

ISSN

0025-7974

Publication Date

September 1996

Volume

75

Issue

5

Start / End Page

279 / 285

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prednisone
  • Polymyositis
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Graft vs Host Disease
  • Female
  • Diagnosis, Differential
 

Citation

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Parker, P., Chao, N. J., Ben-Ezra, J., Slatkin, N., Openshaw, H., Niland, J. C., … Forman, S. J. (1996). Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine (Baltimore), 75(5), 279–285. https://doi.org/10.1097/00005792-199609000-00004
Parker, P., N. J. Chao, J. Ben-Ezra, N. Slatkin, H. Openshaw, J. C. Niland, C. A. Linker, et al. “Polymyositis as a manifestation of chronic graft-versus-host disease.Medicine (Baltimore) 75, no. 5 (September 1996): 279–85. https://doi.org/10.1097/00005792-199609000-00004.
Parker P, Chao NJ, Ben-Ezra J, Slatkin N, Openshaw H, Niland JC, et al. Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine (Baltimore). 1996 Sep;75(5):279–85.
Parker, P., et al. “Polymyositis as a manifestation of chronic graft-versus-host disease.Medicine (Baltimore), vol. 75, no. 5, Sept. 1996, pp. 279–85. Pubmed, doi:10.1097/00005792-199609000-00004.
Parker P, Chao NJ, Ben-Ezra J, Slatkin N, Openshaw H, Niland JC, Linker CA, Greffe BS, Kashyap A, Molina A, Nademanee A, O’Donnell MR, Planas I, Sheibani K, Smith EP, Snyder DS, Spielberger R, Stein AS, Stepan DE, Blume KG, Forman SJ. Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine (Baltimore). 1996 Sep;75(5):279–285.

Published In

Medicine (Baltimore)

DOI

ISSN

0025-7974

Publication Date

September 1996

Volume

75

Issue

5

Start / End Page

279 / 285

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prednisone
  • Polymyositis
  • Middle Aged
  • Male
  • Infant
  • Humans
  • Graft vs Host Disease
  • Female
  • Diagnosis, Differential