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Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans.

Publication ,  Journal Article
Kollins, SH; Rush, CR
Published in: Biol Psychiatry
January 15, 2002

BACKGROUND: Despite a substantial nonhuman literature in the area, few studies have experimentally evaluated the effects of repeated stimulant administration in human participants. This study examined the effects of repeated cocaine in individuals with histories of abuse and dependence. METHODS: Twenty-two individuals with recent histories of cocaine abuse received under double-blind conditions, in pseudorandom order, four administrations of oral cocaine (150 mg [n = 14] or 200 mg [n = 8]) and two administrations of placebo. All administrations were given on separate days. Cardiovascular measures were collected and included heart rate, systolic pressure, diastolic pressure, mean arterial pressure, and pressure rate product. Subject-rated effects were assessed using the Addiction Research Center Inventory (ARCI) and a 15-item drug-effect questionnaire. RESULTS: There were significant differences between placebo days and cocaine days in both cardiovascular and subject-rated effects. Moreover, three of five cardiovascular measures analyzed revealed a significant main effect for day of cocaine administration. A planned follow-up contrast revealed a significant increasing linear trend for each of these variables across days. No significant effects were found for day of administration for the subject-rated items. CONCLUSIONS: These results indicate that, under controlled laboratory conditions, repeated oral cocaine administration may result in sensitization to the cardiovascular effects, but not subject-rated effects.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

January 15, 2002

Volume

51

Issue

2

Start / End Page

143 / 150

Location

United States

Related Subject Headings

  • Psychiatry
  • Personality Inventory
  • Male
  • Humans
  • Heart Rate
  • Female
  • Double-Blind Method
  • Dose-Response Relationship, Drug
  • Cocaine-Related Disorders
  • Cocaine
 

Citation

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Chicago
ICMJE
MLA
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Kollins, S. H., & Rush, C. R. (2002). Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans. Biol Psychiatry, 51(2), 143–150. https://doi.org/10.1016/s0006-3223(01)01288-4
Kollins, Scott H., and Craig R. Rush. “Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans.Biol Psychiatry 51, no. 2 (January 15, 2002): 143–50. https://doi.org/10.1016/s0006-3223(01)01288-4.
Kollins SH, Rush CR. Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans. Biol Psychiatry. 2002 Jan 15;51(2):143–50.
Kollins, Scott H., and Craig R. Rush. “Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans.Biol Psychiatry, vol. 51, no. 2, Jan. 2002, pp. 143–50. Pubmed, doi:10.1016/s0006-3223(01)01288-4.
Kollins SH, Rush CR. Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humans. Biol Psychiatry. 2002 Jan 15;51(2):143–150.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

January 15, 2002

Volume

51

Issue

2

Start / End Page

143 / 150

Location

United States

Related Subject Headings

  • Psychiatry
  • Personality Inventory
  • Male
  • Humans
  • Heart Rate
  • Female
  • Double-Blind Method
  • Dose-Response Relationship, Drug
  • Cocaine-Related Disorders
  • Cocaine