Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve.
Publication
, Journal Article
Sandrock, AW; Matthew, WD
Published in: Brain Res
November 10, 1987
Nerve growth factor (NGF), in addition to its well-known effects as a soluble neurite growth-promoting factor, also appears to promote the elongation of neurites when it is adsorbed to tissue culture substrates. Peripheral nerve Schwann cells appear to possess a receptor for NGF on their surfaces which is induced substantially after axotomy. We have found that the adsorption of NGF onto cryostat sections of the distal stump of previously severed sciatic nerve enhances neurite growth over this tissue. This finding, coupled with the two previous observations, suggests that Schwann cell surface NGF receptors serve to bind to NGF-like growth factors so as to provide favorable surfaces for regenerating peripheral nerve axons.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 10, 1987
Volume
425
Issue
2
Start / End Page
360 / 363
Location
Netherlands
Related Subject Headings
- Sciatic Nerve
- Rats
- Peptides
- Neurology & Neurosurgery
- Nerve Growth Factors
- In Vitro Techniques
- Culture Media
- Axons
- Animals
- 1702 Cognitive Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Sandrock, A. W., & Matthew, W. D. (1987). Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve. Brain Res, 425(2), 360–363. https://doi.org/10.1016/0006-8993(87)90520-8
Sandrock, A. W., and W. D. Matthew. “Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve.” Brain Res 425, no. 2 (November 10, 1987): 360–63. https://doi.org/10.1016/0006-8993(87)90520-8.
Sandrock AW, Matthew WD. Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve. Brain Res. 1987 Nov 10;425(2):360–3.
Sandrock, A. W., and W. D. Matthew. “Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve.” Brain Res, vol. 425, no. 2, Nov. 1987, pp. 360–63. Pubmed, doi:10.1016/0006-8993(87)90520-8.
Sandrock AW, Matthew WD. Substrate-bound nerve growth factor promotes neurite growth in peripheral nerve. Brain Res. 1987 Nov 10;425(2):360–363.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
November 10, 1987
Volume
425
Issue
2
Start / End Page
360 / 363
Location
Netherlands
Related Subject Headings
- Sciatic Nerve
- Rats
- Peptides
- Neurology & Neurosurgery
- Nerve Growth Factors
- In Vitro Techniques
- Culture Media
- Axons
- Animals
- 1702 Cognitive Sciences