Gelation of liposome interior. A novel method for drug encapsulation.
Publication
, Journal Article
Lasic, DD; Frederik, PM; Stuart, MC; Barenholz, Y; McIntosh, TJ
Published in: FEBS Lett
November 9, 1992
Liposomes can be loaded with weak acids and bases, which exist in solutions in equilibrium with membrane permeable uncharged form, using various gradients across their membranes. Because in some cases the estimated drug concentration in the loaded liposomes exceeds their aqueous solubility we investigated the physical state of the liposome encapsulated anticancer drug Doxorubicin. X-Ray diffraction, electron microscopy, and test tube solubility experiments have shown that upon encapsulation the drug molecules form a gel-like phase.
Duke Scholars
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
November 9, 1992
Volume
312
Issue
2-3
Start / End Page
255 / 258
Location
England
Related Subject Headings
- X-Ray Diffraction
- Microscopy, Electron
- Liposomes
- Gels
- Drug Carriers
- Doxorubicin
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0603 Evolutionary Biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lasic, D. D., Frederik, P. M., Stuart, M. C., Barenholz, Y., & McIntosh, T. J. (1992). Gelation of liposome interior. A novel method for drug encapsulation. FEBS Lett, 312(2–3), 255–258. https://doi.org/10.1016/0014-5793(92)80947-f
Lasic, D. D., P. M. Frederik, M. C. Stuart, Y. Barenholz, and T. J. McIntosh. “Gelation of liposome interior. A novel method for drug encapsulation.” FEBS Lett 312, no. 2–3 (November 9, 1992): 255–58. https://doi.org/10.1016/0014-5793(92)80947-f.
Lasic DD, Frederik PM, Stuart MC, Barenholz Y, McIntosh TJ. Gelation of liposome interior. A novel method for drug encapsulation. FEBS Lett. 1992 Nov 9;312(2–3):255–8.
Lasic, D. D., et al. “Gelation of liposome interior. A novel method for drug encapsulation.” FEBS Lett, vol. 312, no. 2–3, Nov. 1992, pp. 255–58. Pubmed, doi:10.1016/0014-5793(92)80947-f.
Lasic DD, Frederik PM, Stuart MC, Barenholz Y, McIntosh TJ. Gelation of liposome interior. A novel method for drug encapsulation. FEBS Lett. 1992 Nov 9;312(2–3):255–258.
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
November 9, 1992
Volume
312
Issue
2-3
Start / End Page
255 / 258
Location
England
Related Subject Headings
- X-Ray Diffraction
- Microscopy, Electron
- Liposomes
- Gels
- Drug Carriers
- Doxorubicin
- Biochemistry & Molecular Biology
- 3101 Biochemistry and cell biology
- 0603 Evolutionary Biology
- 0601 Biochemistry and Cell Biology