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Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts.

Publication ,  Journal Article
Storek, J; Gooley, T; Witherspoon, RP; Sullivan, KM; Storb, R
Published in: Am J Hematol
February 1997

Survivors of allogeneic marrow transplants are immunodeficient for at least 1 year after grafting. Multiple defects of immunity have been found; however, it is not known which defect primarily accounts for the high infectious morbidity of these patients. Twenty-nine allograft recipients who were in complete remission of the original disease were examined for the following parameters of immunity at 1 year after transplant: infection score (gauging the number and severity of infections within the 6 months prior to the annual exam), serum total IgM, IgG, and IgA, anti-Haemophilus influenzae IgG, anti-Streptococcus pneumoniae IgG, skin test reactivity, and the blood counts of B cells, CD4+ T cells, CD8+ T cells, and their subsets. THe only parameter inversely correlated with the infection score was CD4+ T cell count (P = 0.005 in univariable analysis, P = 0.06 in multivariable analysis). We conclude that infectious morbidity of long-term transplant survivors is related to the reconstitution of CD4+ T cells.

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Published In

Am J Hematol

DOI

ISSN

0361-8609

Publication Date

February 1997

Volume

54

Issue

2

Start / End Page

131 / 138

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Time Factors
  • Survival Analysis
  • Morbidity
  • Middle Aged
  • Male
  • Lymphocyte Count
  • Infections
  • Immunology
  • Humans
 

Citation

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Storek, J., Gooley, T., Witherspoon, R. P., Sullivan, K. M., & Storb, R. (1997). Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol, 54(2), 131–138. https://doi.org/10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y
Storek, J., T. Gooley, R. P. Witherspoon, K. M. Sullivan, and R. Storb. “Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts.Am J Hematol 54, no. 2 (February 1997): 131–38. https://doi.org/10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y.
Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol. 1997 Feb;54(2):131–8.
Storek, J., et al. “Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts.Am J Hematol, vol. 54, no. 2, Feb. 1997, pp. 131–38. Pubmed, doi:10.1002/(sici)1096-8652(199702)54:2<131::aid-ajh6>3.0.co;2-y.
Storek J, Gooley T, Witherspoon RP, Sullivan KM, Storb R. Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts. Am J Hematol. 1997 Feb;54(2):131–138.
Journal cover image

Published In

Am J Hematol

DOI

ISSN

0361-8609

Publication Date

February 1997

Volume

54

Issue

2

Start / End Page

131 / 138

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Time Factors
  • Survival Analysis
  • Morbidity
  • Middle Aged
  • Male
  • Lymphocyte Count
  • Infections
  • Immunology
  • Humans