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Polymyositis as a manifestation of chronic graft-versus-host disease.

Publication ,  Journal Article
Stevens, AM; Sullivan, KM; Nelson, JL
Published in: Rheumatology (Oxford)
January 2003

OBJECTIVE: Chronic graft-versus-host disease (GVHD) after haematopoietic stem cell transplantation (HSCT) has similarities to some idiopathic autoimmune diseases, including polymyositis. To investigate the relationship between chronic GVHD and idiopathic myositis we conducted a detailed analysis of all cases of myositis occurring in a large series of HSCT patients. METHODS: We conducted a retrospective chart review of all cases of myositis that developed in 7161 patients who underwent HSCT at the Fred Hutchinson Cancer Research Center between 1969 and 1999. RESULTS: Among 1859 individuals who developed chronic GVHD, 12 developed myositis. No patients developed myositis without chronic GVHD. Myositis was first identified between 7 and 55 months after transplantation. In histopathology, electromyography, laboratory values and response to immunosuppressive therapy, the cases resembled idiopathic polymyositis. Autoantibodies were found in eight cases. CONCLUSIONS: Myositis in the chronic GVHD population occurred with an incidence higher than expected by chance, suggesting that muscle may be a target tissue for chronic GVHD. Recent studies have implicated allogeneic cells persisting after maternal-fetal cell transfer in selected autoimmune diseases, including myositis. This report lends support to the possibility that both idiopathic myositis and chronic GVHD-related myositis could involve allo-autoimmune responses.

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Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

January 2003

Volume

42

Issue

1

Start / End Page

34 / 39

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Retrospective Studies
  • Polymyositis
  • Middle Aged
  • Male
  • Humans
  • Histocompatibility Testing
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Follow-Up Studies
 

Citation

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Stevens, A. M., Sullivan, K. M., & Nelson, J. L. (2003). Polymyositis as a manifestation of chronic graft-versus-host disease. Rheumatology (Oxford), 42(1), 34–39. https://doi.org/10.1093/rheumatology/keg025
Stevens, A. M., K. M. Sullivan, and J. L. Nelson. “Polymyositis as a manifestation of chronic graft-versus-host disease.Rheumatology (Oxford) 42, no. 1 (January 2003): 34–39. https://doi.org/10.1093/rheumatology/keg025.
Stevens AM, Sullivan KM, Nelson JL. Polymyositis as a manifestation of chronic graft-versus-host disease. Rheumatology (Oxford). 2003 Jan;42(1):34–9.
Stevens, A. M., et al. “Polymyositis as a manifestation of chronic graft-versus-host disease.Rheumatology (Oxford), vol. 42, no. 1, Jan. 2003, pp. 34–39. Pubmed, doi:10.1093/rheumatology/keg025.
Stevens AM, Sullivan KM, Nelson JL. Polymyositis as a manifestation of chronic graft-versus-host disease. Rheumatology (Oxford). 2003 Jan;42(1):34–39.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

ISSN

1462-0324

Publication Date

January 2003

Volume

42

Issue

1

Start / End Page

34 / 39

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Retrospective Studies
  • Polymyositis
  • Middle Aged
  • Male
  • Humans
  • Histocompatibility Testing
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Follow-Up Studies