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Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients.

Publication ,  Journal Article
Bush, NE; Donaldson, GW; Haberman, MH; Dacanay, R; Sullivan, KM
Published in: Biol Blood Marrow Transplant
2000

Emerging literature suggests that quality of life (QOL) after bone marrow transplantation is relatively good but is accompanied in some patients by a variety of residual difficulties. The studies supporting this finding, however, have been somewhat limited in scale, scope, design, and analysis. We comprehensively measured changes in multidimensional QOL in a 4-year longitudinal follow-up of 415 adult patients who received hematopoietic stem cell transplants at Fred Hutchinson Cancer Research Center. Questionnaire packets containing 271 items were mailed annually posttransplantation to patients' homes. Standard methods of analysis yielded conditional estimates depending on compliance and survival, whereas new, likelihood-based methods generated unconditional estimates applicable to the full intent-to-treat population. Typical QOL levels generally remained high over the entire study period. Most QOL functioning significantly improved over 4 years, with the remainder showing no important decrement. Although isolated problem areas, such as sexual dissatisfaction, did emerge, the level of dysfunction for most physical and psychological scales remained below 30% of scale maxima. Broadly similar results were obtained for conditional estimation, which may contain an optimistic bias, and for unconditional estimation, which largely avoids the bias. Because concurrence was obtained between the 2 types of estimation, we conclude that most patients really do experience good levels of QOL in the 4 years after transplantation. Although some problems can be anticipated, typical patients can look forward to a QOL after transplantation that is broadly comparable to that of the normal population.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

2000

Volume

6

Issue

5A

Start / End Page

576 / 591

Location

United States

Related Subject Headings

  • Survivors
  • Surveys and Questionnaires
  • Stress, Psychological
  • Social Support
  • Sleep Wake Disorders
  • Sexual Dysfunction, Physiological
  • Quality of Life
  • Prospective Studies
  • Pain
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bush, N. E., Donaldson, G. W., Haberman, M. H., Dacanay, R., & Sullivan, K. M. (2000). Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients. Biol Blood Marrow Transplant, 6(5A), 576–591. https://doi.org/10.1016/s1083-8791(00)70067-x
Bush, N. E., G. W. Donaldson, M. H. Haberman, R. Dacanay, and K. M. Sullivan. “Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients.Biol Blood Marrow Transplant 6, no. 5A (2000): 576–91. https://doi.org/10.1016/s1083-8791(00)70067-x.
Bush NE, Donaldson GW, Haberman MH, Dacanay R, Sullivan KM. Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients. Biol Blood Marrow Transplant. 2000;6(5A):576–91.
Bush, N. E., et al. “Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients.Biol Blood Marrow Transplant, vol. 6, no. 5A, 2000, pp. 576–91. Pubmed, doi:10.1016/s1083-8791(00)70067-x.
Bush NE, Donaldson GW, Haberman MH, Dacanay R, Sullivan KM. Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients. Biol Blood Marrow Transplant. 2000;6(5A):576–591.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

2000

Volume

6

Issue

5A

Start / End Page

576 / 591

Location

United States

Related Subject Headings

  • Survivors
  • Surveys and Questionnaires
  • Stress, Psychological
  • Social Support
  • Sleep Wake Disorders
  • Sexual Dysfunction, Physiological
  • Quality of Life
  • Prospective Studies
  • Pain
  • Middle Aged