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Bone Marrow Transplantation for Non-Malignant Disease.

Publication ,  Journal Article
Sullivan, KM; Parkman, R; Walters, MC
Published in: Hematology Am Soc Hematol Educ Program
2000

This article reviews the experience in hematopoietic stem cell transplantation (HSCT) for non-malignant disease. HSCT has long been applied as treatment of life-threatening congenital immunodeficiency and metabolic diseases. In Section I, Dr. Parkman reviews that experience for severe combined immunodeficiency, Wiscott-Aldrich syndrome, hyper IGM syndrome, Chédiak-Higashi disease and hereditary lymphohistiocytosis. The value of HSCT in genetic metabolic diseases such as osteopetrosis, osteogenesis imperfecta and the storage diseases are reviewed. In Section II, Dr. Walters reviews the experience over the last decade with allogeneic stem cell transplantation in patients with thalassemia major and sickle cell disease. In Section III, Dr. Sullivan reviews the more recent investigations using stem cell transplantation in patients with advanced autoimmune diseases such as systemic sclerosis, systemic lupus erythematosus, multiple sclerosis and juvenile rheumatoid arthritis. The pathogenesis and outcome with conventional care of these patients, the selection criteria and current results for HSCT, and the future directions in clinical research and patient care using this modality are addressed.

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Published In

Hematology Am Soc Hematol Educ Program

DOI

EISSN

1520-4383

Publication Date

2000

Start / End Page

319 / 338

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
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Sullivan, K. M., Parkman, R., & Walters, M. C. (2000). Bone Marrow Transplantation for Non-Malignant Disease. Hematology Am Soc Hematol Educ Program, 319–338. https://doi.org/10.1182/asheducation-2000.1.319
Sullivan, Keith M., Robertson Parkman, and Mark C. Walters. “Bone Marrow Transplantation for Non-Malignant Disease.Hematology Am Soc Hematol Educ Program, 2000, 319–38. https://doi.org/10.1182/asheducation-2000.1.319.
Sullivan KM, Parkman R, Walters MC. Bone Marrow Transplantation for Non-Malignant Disease. Hematology Am Soc Hematol Educ Program. 2000;319–38.
Sullivan, Keith M., et al. “Bone Marrow Transplantation for Non-Malignant Disease.Hematology Am Soc Hematol Educ Program, 2000, pp. 319–38. Pubmed, doi:10.1182/asheducation-2000.1.319.
Sullivan KM, Parkman R, Walters MC. Bone Marrow Transplantation for Non-Malignant Disease. Hematology Am Soc Hematol Educ Program. 2000;319–338.

Published In

Hematology Am Soc Hematol Educ Program

DOI

EISSN

1520-4383

Publication Date

2000

Start / End Page

319 / 338

Location

United States