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Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease.

Publication ,  Journal Article
Storek, J; Gooley, T; Siadak, M; Bensinger, WI; Maloney, DG; Chauncey, TR; Flowers, M; Sullivan, KM; Witherspoon, RP; Rowley, SD; Hansen, JA ...
Published in: Blood
December 15, 1997

Chronic graft-versus-host disease (GVHD) is likely caused by donor T lymphocytes. Because unmodified blood stem cell grafts contain one log more T lymphocytes than unmodified marrow grafts, we evaluated the incidence of chronic GVHD in previously reported 37 blood stem cell recipients and 37 computer-matched historical control marrow recipients (Bensinger et al, Blood 88:2794, 1996). All patients have been followed until death, relapse, or occurrence of chronic GVHD or for a minimum of 2 years. In a univariable proportional hazards regression model, the relative risk of developing clinical chronic GVHD (includes clinical limited and clinical extensive disease) by 2 years posttransplant among the peripheral blood stem cell recipients compared with the marrow recipients was 2.22 (95% confidence interval, 1.04 to 4.74; P = .039). For clinical extensive chronic GVHD, the relative risk was 2.37 (95% confidence interval, 1.07 to 5. 29; P = .035). In multivariable analyses, considering also the covariables of patient age, patient cytomegalovirus serostatus, and donor cytomegalovirus serostatus, the relative risks of clinical chronic GVHD and clinical extensive chronic GVHD were also greater than 2 (P < .05). We conclude that the transplantation of unmanipulated filgrastim-mobilized blood stem cells may result in a relatively high incidence of chronic GVHD.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

December 15, 1997

Volume

90

Issue

12

Start / End Page

4705 / 4709

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Risk
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Chronic Disease
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Storek, J., Gooley, T., Siadak, M., Bensinger, W. I., Maloney, D. G., Chauncey, T. R., … Appelbaum, F. R. (1997). Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease. Blood, 90(12), 4705–4709.
Storek, J., T. Gooley, M. Siadak, W. I. Bensinger, D. G. Maloney, T. R. Chauncey, M. Flowers, et al. “Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease.Blood 90, no. 12 (December 15, 1997): 4705–9.
Storek J, Gooley T, Siadak M, Bensinger WI, Maloney DG, Chauncey TR, et al. Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease. Blood. 1997 Dec 15;90(12):4705–9.
Storek J, Gooley T, Siadak M, Bensinger WI, Maloney DG, Chauncey TR, Flowers M, Sullivan KM, Witherspoon RP, Rowley SD, Hansen JA, Storb R, Appelbaum FR. Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease. Blood. 1997 Dec 15;90(12):4705–4709.

Published In

Blood

ISSN

0006-4971

Publication Date

December 15, 1997

Volume

90

Issue

12

Start / End Page

4705 / 4709

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Risk
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Chronic Disease
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology