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Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease.

Publication ,  Journal Article
deGast, GC; Beatty, PG; Amos, D; Mickelson, EM; Sullivan, KM; Anderson, JE; Giblett, ER; Appelbaum, F; Storb, R; Deeg, HJ
Published in: Bone Marrow Transplant
April 1991

The effect of random red cell transfusions given shortly before allogeneic bone marrow transplantation (BMT) was evaluated in 969 leukemic patients transplanted from an HLA-identical sibling donor. Patients were divided into two groups: 501 who received a transfusion shortly before BMT, and 468 who did not. Both groups had a similar incidence of acute graft-versus-host disease (GVHD), but the recently-transfused group had a significantly lower incidence of chronic GVHD (35.9% vs 48.9%). These differences remained significant in a multivariate analysis of time to chronic GVHD (p = 0.022), taking into account other differences between the two groups and known risk factors for chronic GVHD.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

April 1991

Volume

7

Issue

4

Start / End Page

293 / 295

Location

England

Related Subject Headings

  • Washington
  • Retrospective Studies
  • Leukemia
  • Incidence
  • Immunology
  • Humans
  • Histocompatibility
  • Graft vs Host Disease
  • Graft Enhancement, Immunologic
  • Chronic Disease
 

Citation

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deGast, G. C., Beatty, P. G., Amos, D., Mickelson, E. M., Sullivan, K. M., Anderson, J. E., … Deeg, H. J. (1991). Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease. Bone Marrow Transplant, 7(4), 293–295.
deGast, G. C., P. G. Beatty, D. Amos, E. M. Mickelson, K. M. Sullivan, J. E. Anderson, E. R. Giblett, F. Appelbaum, R. Storb, and H. J. Deeg. “Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease.Bone Marrow Transplant 7, no. 4 (April 1991): 293–95.
deGast GC, Beatty PG, Amos D, Mickelson EM, Sullivan KM, Anderson JE, et al. Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease. Bone Marrow Transplant. 1991 Apr;7(4):293–5.
deGast GC, Beatty PG, Amos D, Mickelson EM, Sullivan KM, Anderson JE, Giblett ER, Appelbaum F, Storb R, Deeg HJ. Transfusions shortly before HLA-matched marrow transplantation for leukemia are associated with a decrease in chronic graft-versus-host disease. Bone Marrow Transplant. 1991 Apr;7(4):293–295.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

April 1991

Volume

7

Issue

4

Start / End Page

293 / 295

Location

England

Related Subject Headings

  • Washington
  • Retrospective Studies
  • Leukemia
  • Incidence
  • Immunology
  • Humans
  • Histocompatibility
  • Graft vs Host Disease
  • Graft Enhancement, Immunologic
  • Chronic Disease