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Analysis of injury in complex organ preservation.

Publication ,  Journal Article
Weinerth, JL; Abbott, WM
Published in: Ann Surg
December 1974

A biochemical assay of renal viability previously described for rabbits is validated in a canine model using anoxia, hypothermia, and hypothermic perfusion. The assay correlated well with the decree of anoxic injury and protective effect of hypothermia. It was found to be unable to document significant injury when pulsatile perfusion was added to the system and resulted in nonviable canine kidneys. Apparent vascular damage with interstitial hemorrhage occurred after the perfusion and was not predictable by the use of the assay system. The limitations of any assay for organ viability after complex preservation maneuvers is the result of a multiplicity of injurious factors surrounding the preservation or as a consequence of the preservation. No single assay system will be adequate for protection of organ viability during or after preservation as long as the types of injury are multiple. Is is suggested that great care be used in defining possible injurious factors associated with given preservation maneuver and that specific assays be utilized to document the effects of each of these factors. The more complex the preservation system employed; the more complex the assay system needed.

Duke Scholars

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1974

Volume

180

Issue

6

Start / End Page

840 / 846

Location

United States

Related Subject Headings

  • Tissue Preservation
  • Time Factors
  • Surgery
  • Perfusion
  • Organ Preservation
  • Nephrectomy
  • Male
  • Lactates
  • L-Lactate Dehydrogenase
  • Kidney Transplantation
 

Citation

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Weinerth, J. L., & Abbott, W. M. (1974). Analysis of injury in complex organ preservation. Ann Surg, 180(6), 840–846. https://doi.org/10.1097/00000658-197412000-00008
Weinerth, J. L., and W. M. Abbott. “Analysis of injury in complex organ preservation.Ann Surg 180, no. 6 (December 1974): 840–46. https://doi.org/10.1097/00000658-197412000-00008.
Weinerth JL, Abbott WM. Analysis of injury in complex organ preservation. Ann Surg. 1974 Dec;180(6):840–6.
Weinerth, J. L., and W. M. Abbott. “Analysis of injury in complex organ preservation.Ann Surg, vol. 180, no. 6, Dec. 1974, pp. 840–46. Pubmed, doi:10.1097/00000658-197412000-00008.
Weinerth JL, Abbott WM. Analysis of injury in complex organ preservation. Ann Surg. 1974 Dec;180(6):840–846.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

December 1974

Volume

180

Issue

6

Start / End Page

840 / 846

Location

United States

Related Subject Headings

  • Tissue Preservation
  • Time Factors
  • Surgery
  • Perfusion
  • Organ Preservation
  • Nephrectomy
  • Male
  • Lactates
  • L-Lactate Dehydrogenase
  • Kidney Transplantation