Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.
Publication
, Journal Article
Collins, S; Caron, MG; Lefkowitz, RJ
Published in: Annu Rev Physiol
1991
Multiple mechanisms contribute to the regulation of G protein-coupled receptors and their transmembrane signaling. Post-translational modifications of the receptors, such as phosphorylation, and changes in receptor gene expression can occur in either a strictly agonist-dependent fashion or through second messenger-mediated autoregulation. We have shown that modulation of receptor gene expression contributes to the responsiveness of adrenergic and related receptors. Recent evidence for post-transcriptional regulation, as well as the stimulation of transcription in an autoregulatory manner, indicates the unanticipated variety and complexity of mechanisms regulating adrenergic receptor responsiveness.
Duke Scholars
Published In
Annu Rev Physiol
DOI
ISSN
0066-4278
Publication Date
1991
Volume
53
Start / End Page
497 / 508
Location
United States
Related Subject Headings
- Up-Regulation
- Receptors, Adrenergic
- Physiology
- Humans
- Gene Expression Regulation
- Animals
- 3208 Medical physiology
- 3109 Zoology
- 11 Medical and Health Sciences
- 06 Biological Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Collins, S., Caron, M. G., & Lefkowitz, R. J. (1991). Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol, 53, 497–508. https://doi.org/10.1146/annurev.ph.53.030191.002433
Collins, S., M. G. Caron, and R. J. Lefkowitz. “Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.” Annu Rev Physiol 53 (1991): 497–508. https://doi.org/10.1146/annurev.ph.53.030191.002433.
Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol. 1991;53:497–508.
Collins, S., et al. “Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.” Annu Rev Physiol, vol. 53, 1991, pp. 497–508. Pubmed, doi:10.1146/annurev.ph.53.030191.002433.
Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol. 1991;53:497–508.
Published In
Annu Rev Physiol
DOI
ISSN
0066-4278
Publication Date
1991
Volume
53
Start / End Page
497 / 508
Location
United States
Related Subject Headings
- Up-Regulation
- Receptors, Adrenergic
- Physiology
- Humans
- Gene Expression Regulation
- Animals
- 3208 Medical physiology
- 3109 Zoology
- 11 Medical and Health Sciences
- 06 Biological Sciences