cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.
Publication
, Journal Article
Benovic, JL; Stone, WC; Huebner, K; Croce, C; Caron, MG; Lefkowitz, RJ
Published in: FEBS Lett
May 20, 1991
The beta-adrenergic receptor kinase (beta ARK) mediates agonist-dependent phosphorylation of the beta 2-adrenergic and related G protein-coupled receptors. A cDNA encoding bovine beta ARK has recently been isolated. In this work we have isolated a cDNA encoding human beta ARK from a retinal cDNA library. The cDNA encodes a protein of 689 amino acids with an overall 98.0% amino acid and 92.5% nucleotide identity with bovine beta ARK. Chromosomal location of the human beta ARK gene was determined by correlating the presence of the beta ARK locus with retention of a specific human chromosome in a rodent-human hybrid panel. This analysis revealed that the human beta ARK locus segregated with the long arm of chromosome 11, centromeric to 11q13.
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Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
May 20, 1991
Volume
283
Issue
1
Start / End Page
122 / 126
Location
England
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Rodentia
- Protein Kinases
- Molecular Sequence Data
- Hybrid Cells
- Humans
- G-Protein-Coupled Receptor Kinase 2
- DNA
- Cyclic AMP-Dependent Protein Kinases
- Cloning, Molecular
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ICMJE
MLA
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Benovic, J. L., Stone, W. C., Huebner, K., Croce, C., Caron, M. G., & Lefkowitz, R. J. (1991). cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. FEBS Lett, 283(1), 122–126. https://doi.org/10.1016/0014-5793(91)80568-n
Benovic, J. L., W. C. Stone, K. Huebner, C. Croce, M. G. Caron, and R. J. Lefkowitz. “cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.” FEBS Lett 283, no. 1 (May 20, 1991): 122–26. https://doi.org/10.1016/0014-5793(91)80568-n.
Benovic JL, Stone WC, Huebner K, Croce C, Caron MG, Lefkowitz RJ. cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. FEBS Lett. 1991 May 20;283(1):122–6.
Benovic, J. L., et al. “cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.” FEBS Lett, vol. 283, no. 1, May 1991, pp. 122–26. Pubmed, doi:10.1016/0014-5793(91)80568-n.
Benovic JL, Stone WC, Huebner K, Croce C, Caron MG, Lefkowitz RJ. cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase. FEBS Lett. 1991 May 20;283(1):122–126.
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
May 20, 1991
Volume
283
Issue
1
Start / End Page
122 / 126
Location
England
Related Subject Headings
- beta-Adrenergic Receptor Kinases
- Rodentia
- Protein Kinases
- Molecular Sequence Data
- Hybrid Cells
- Humans
- G-Protein-Coupled Receptor Kinase 2
- DNA
- Cyclic AMP-Dependent Protein Kinases
- Cloning, Molecular