Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.
Publication
, Journal Article
Lefkowitz, RJ; Caron, MG
Published in: J Mol Cell Cardiol
September 1986
The various subtypes of adrenergic receptors represent distinct structural entities which are coupled in different ways to two major transmembrane signalling systems, the adenylate cyclase and phosphatidyl-inositol pathways. Recent evidence suggests that the functional linkage of both beta and alpha 1-adrenergic receptors to their respective effector systems is regulated by covalent modification of the receptors by phosphorylation-dephosphorylation reactions. Receptor phosphorylation appears to lead to desensitization of the biological response to receptor stimulation. Several kinases including protein kinase A, protein kinase C and a cAMP independent kinase appear to participate in these reactions.
Duke Scholars
Published In
J Mol Cell Cardiol
DOI
ISSN
0022-2828
Publication Date
September 1986
Volume
18
Issue
9
Start / End Page
885 / 895
Location
England
Related Subject Headings
- Type C Phospholipases
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, alpha
- Receptors, Adrenergic
- Protein Kinases
- Protein Kinase C
- Phosphorylation
- Molecular Weight
- Isoproterenol
- GTP-Binding Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Lefkowitz, R. J., & Caron, M. G. (1986). Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. J Mol Cell Cardiol, 18(9), 885–895. https://doi.org/10.1016/s0022-2828(86)80003-7
Lefkowitz, R. J., and M. G. Caron. “Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.” J Mol Cell Cardiol 18, no. 9 (September 1986): 885–95. https://doi.org/10.1016/s0022-2828(86)80003-7.
Lefkowitz RJ, Caron MG. Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. J Mol Cell Cardiol. 1986 Sep;18(9):885–95.
Lefkowitz, R. J., and M. G. Caron. “Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.” J Mol Cell Cardiol, vol. 18, no. 9, Sept. 1986, pp. 885–95. Pubmed, doi:10.1016/s0022-2828(86)80003-7.
Lefkowitz RJ, Caron MG. Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation. J Mol Cell Cardiol. 1986 Sep;18(9):885–895.
Published In
J Mol Cell Cardiol
DOI
ISSN
0022-2828
Publication Date
September 1986
Volume
18
Issue
9
Start / End Page
885 / 895
Location
England
Related Subject Headings
- Type C Phospholipases
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, alpha
- Receptors, Adrenergic
- Protein Kinases
- Protein Kinase C
- Phosphorylation
- Molecular Weight
- Isoproterenol
- GTP-Binding Proteins