Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
Publication
, Journal Article
Cotecchia, S; Schwinn, DA; Randall, RR; Lefkowitz, RJ; Caron, MG; Kobilka, BK
Published in: Proc Natl Acad Sci U S A
October 1988
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the receptor protein purified from DDT1MF-2 smooth muscle cells. The deduced amino acid sequence encodes a 515-residue polypeptide that shows the most sequence identity with the other adrenergic receptors and the putative protein product of the related clone G-21. Similarities with the muscarinic cholinergic receptors are also evident. Expression studies in COS-7 cells confirm that we have cloned the alpha 1-adrenergic receptor that couples to inositol phospholipid metabolism.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1988
Volume
85
Issue
19
Start / End Page
7159 / 7163
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Phosphatidylinositols
- Molecular Sequence Data
- Gene Expression Regulation
- GTP-Binding Proteins
- DNA
- Cricetinae
- Cloning, Molecular
- Base Sequence
- Animals
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Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R. J., Caron, M. G., & Kobilka, B. K. (1988). Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A, 85(19), 7159–7163. https://doi.org/10.1073/pnas.85.19.7159
Cotecchia, S., D. A. Schwinn, R. R. Randall, R. J. Lefkowitz, M. G. Caron, and B. K. Kobilka. “Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.” Proc Natl Acad Sci U S A 85, no. 19 (October 1988): 7159–63. https://doi.org/10.1073/pnas.85.19.7159.
Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7159–63.
Cotecchia, S., et al. “Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.” Proc Natl Acad Sci U S A, vol. 85, no. 19, Oct. 1988, pp. 7159–63. Pubmed, doi:10.1073/pnas.85.19.7159.
Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7159–7163.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1988
Volume
85
Issue
19
Start / End Page
7159 / 7163
Location
United States
Related Subject Headings
- Receptors, Adrenergic, alpha
- Phosphatidylinositols
- Molecular Sequence Data
- Gene Expression Regulation
- GTP-Binding Proteins
- DNA
- Cricetinae
- Cloning, Molecular
- Base Sequence
- Animals