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Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents.

Publication ,  Journal Article
Gonzalez, P; Rao, PV; Nuñez, SB; Zigler, JS
Published in: Mol Biol Evol
September 1995

Zeta-crystallin/quinone reductase (CRYZ) is an NADPH oxidoreductase expressed at very high levels in the lenses of two groups of mammals: camelids and some hystricomorph rodents. It is also expressed at very low levels in all other species tested. Comparative analysis of the mechanisms mediating the high expression of this enzyme/crystallin in the lens of the Ilama (Lama guanacoe) and the guinea pig (Cavia porcellus) provided evidence for independent recruitment of this enzyme as a lens crystallin in both species and allowed us to elucidate for the first time the mechanism of lens recruitment of an enzyme-crystallin. The data presented here show that in both species such recruitment most likely occurred through the generation of new lens promoters from nonfunctional intron sequences by the accumulation of point mutations and/or small deletions and insertions. These results further support the idea that recruitment of CRYZ resulted from an adaptive process in which the high expression of CRYZ in the lens provides some selective advantage rather than from a purely neutral evolutionary process.

Duke Scholars

Published In

Mol Biol Evol

DOI

ISSN

0737-4038

Publication Date

September 1995

Volume

12

Issue

5

Start / End Page

773 / 781

Location

United States

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Rats
  • Polymerase Chain Reaction
  • NAD(P)H Dehydrogenase (Quinone)
  • Molecular Sequence Data
  • Lens, Crystalline
  • Humans
  • Guinea Pigs
  • Evolutionary Biology
 

Citation

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Gonzalez, P., Rao, P. V., Nuñez, S. B., & Zigler, J. S. (1995). Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents. Mol Biol Evol, 12(5), 773–781. https://doi.org/10.1093/oxfordjournals.molbev.a040255
Gonzalez, P., P. V. Rao, S. B. Nuñez, and J. S. Zigler. “Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents.Mol Biol Evol 12, no. 5 (September 1995): 773–81. https://doi.org/10.1093/oxfordjournals.molbev.a040255.
Gonzalez, P., et al. “Evidence for independent recruitment of zeta-crystallin/quinone reductase (CRYZ) as a crystallin in camelids and hystricomorph rodents.Mol Biol Evol, vol. 12, no. 5, Sept. 1995, pp. 773–81. Pubmed, doi:10.1093/oxfordjournals.molbev.a040255.
Journal cover image

Published In

Mol Biol Evol

DOI

ISSN

0737-4038

Publication Date

September 1995

Volume

12

Issue

5

Start / End Page

773 / 781

Location

United States

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Sequence Homology, Amino Acid
  • Rats
  • Polymerase Chain Reaction
  • NAD(P)H Dehydrogenase (Quinone)
  • Molecular Sequence Data
  • Lens, Crystalline
  • Humans
  • Guinea Pigs
  • Evolutionary Biology