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Remodeling muscles with calcineurin.

Publication ,  Journal Article
Olson, EN; Williams, RS
Published in: Bioessays
June 2000

Ca(2+) signaling plays a central role in hypertrophic growth of cardiac and skeletal muscle in response to mechanical load and a variety of signals. However, the mechanisms whereby alterations in Ca(2+) in the cytoplasm activate the hypertrophic response and result in longterm changes in muscle gene expression are unclear. The Ca(2+), calmodulin-dependent protein phosphatase calcineurin has been proposed to control cardiac and skeletal muscle hypertrophy by acting as a Ca(2+) sensor that couples prolonged changes in Ca(2+) levels to reprogramming of muscle gene expression. Calcineurin also controls the contractile and metabolic properties of skeletal muscle by activating the slow muscle fiber-specific gene program, which is dependent on Ca(2+) signaling. Transcription factors of the NFAT and MEF2 families serve as endpoints for the signaling pathways whereby calcineurin controls muscle hypertrophy and fiber-type. We consider these findings in the context of a model for Ca(2+)-regulated gene expression in muscle cells and discuss potential implications of these findings for pharmacologic modification of cardiac and skeletal muscle function. BioEssays 22:510-519, 2000.

Duke Scholars

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

June 2000

Volume

22

Issue

6

Start / End Page

510 / 519

Location

United States

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Regeneration
  • Nuclear Proteins
  • NFATC Transcription Factors
  • Muscles
  • Muscle, Skeletal
  • Hypertrophy
  • Humans
  • Gene Expression
 

Citation

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Olson, E. N., & Williams, R. S. (2000). Remodeling muscles with calcineurin. Bioessays, 22(6), 510–519. https://doi.org/10.1002/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1
Olson, E. N., and R. S. Williams. “Remodeling muscles with calcineurin.Bioessays 22, no. 6 (June 2000): 510–19. https://doi.org/10.1002/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1.
Olson EN, Williams RS. Remodeling muscles with calcineurin. Bioessays. 2000 Jun;22(6):510–9.
Olson, E. N., and R. S. Williams. “Remodeling muscles with calcineurin.Bioessays, vol. 22, no. 6, June 2000, pp. 510–19. Pubmed, doi:10.1002/(SICI)1521-1878(200006)22:6<510::AID-BIES4>3.0.CO;2-1.
Olson EN, Williams RS. Remodeling muscles with calcineurin. Bioessays. 2000 Jun;22(6):510–519.
Journal cover image

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

June 2000

Volume

22

Issue

6

Start / End Page

510 / 519

Location

United States

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Regeneration
  • Nuclear Proteins
  • NFATC Transcription Factors
  • Muscles
  • Muscle, Skeletal
  • Hypertrophy
  • Humans
  • Gene Expression