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Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.

Publication ,  Journal Article
Radford, NB; Fina, M; Benjamin, IJ; Moreadith, RW; Graves, KH; Zhao, P; Gavva, S; Wiethoff, A; Sherry, AD; Malloy, CR; Williams, RS
Published in: Proc Natl Acad Sci U S A
March 19, 1996
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Heat shock proteins are proposed to limit injury resulting from diverse environmental stresses, but direct metabolic evidence for such a cytoprotective function in vertebrates has been largely limited to studies of cultured cells. We generated lines of transgenic mice to express human 70-kDa heat shock protein constitutively in the myocardium. Hearts isolated from these animals demonstrated enhanced recovery of high energy phosphate stores and correction of metabolic acidosis following brief periods of global ischemia sufficient to induce sustained abnormalities of these variables in hearts from nontransgenic littermates. These data demonstrate a direct cardioprotective effect of 70-kDa heat shock protein to enhance postischemic recovery of the intact heart.

Duke Scholars

Robert Sanders Williams
Author Robert Sanders Williams Medicine, Cardiology
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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.93.6.2339

ISSN

0027-8424

Publication Date

March 19, 1996

Volume

93

Issue

6

Start / End Page

2339 / 2342

Location

United States

Related Subject Headings

  • Reperfusion Injury
  • Myocardium
  • Mice, Transgenic
  • Mice
  • Magnetic Resonance Spectroscopy
  • Humans
  • HSP70 Heat-Shock Proteins
  • Energy Metabolism
  • Animals
  • Adenine Nucleotides
 

Citation

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Radford, N. B., Fina, M., Benjamin, I. J., Moreadith, R. W., Graves, K. H., Zhao, P., … Williams, R. S. (1996). Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A, 93(6), 2339–2342. https://doi.org/10.1073/pnas.93.6.2339
Radford, N. B., M. Fina, I. J. Benjamin, R. W. Moreadith, K. H. Graves, P. Zhao, S. Gavva, et al. “Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.” Proc Natl Acad Sci U S A 93, no. 6 (March 19, 1996): 2339–42. https://doi.org/10.1073/pnas.93.6.2339.
Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, et al. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2339–42.
Radford, N. B., et al. “Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.” Proc Natl Acad Sci U S A, vol. 93, no. 6, Mar. 1996, pp. 2339–42. Pubmed, doi:10.1073/pnas.93.6.2339.
Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2339–2342.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.93.6.2339

ISSN

0027-8424

Publication Date

March 19, 1996

Volume

93

Issue

6

Start / End Page

2339 / 2342

Location

United States

Related Subject Headings

  • Reperfusion Injury
  • Myocardium
  • Mice, Transgenic
  • Mice
  • Magnetic Resonance Spectroscopy
  • Humans
  • HSP70 Heat-Shock Proteins
  • Energy Metabolism
  • Animals
  • Adenine Nucleotides