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Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development.

Publication ,  Journal Article
Banin, E; Cideciyan, AV; Alemán, TS; Petters, RM; Wong, F; Milam, AH; Jacobson, SG
Published in: Neuron
July 1999

Rod-specific photoreceptor dystrophies are complicated by the delayed death of genetically normal neighboring cones. In transgenic (Tg) swine with a rod-specific (rhodopsin) gene mutation, cone photoreceptor physiology was normal for months but later declined, consistent with delayed cone cell death. Surprisingly, cone postreceptoral function was markedly abnormal when cone photoreceptor physiology was still normal. The defect was localized to hyperpolarizing cells postsynaptic to the middle wavelength-sensitive cones. Recordings throughout postnatal development indicated a failure of cone circuitry maturation, a novel mechanism of secondary cone abnormality in rod dystrophy. The results have implications for therapy for human retinal dystrophies and raise the possibility that rod afferent activity plays a role in the postnatal maturation of cone retinal circuitry.

Duke Scholars

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

July 1999

Volume

23

Issue

3

Start / End Page

549 / 557

Location

United States

Related Subject Headings

  • Synapses
  • Swine
  • Rhodopsin
  • Retinitis Pigmentosa
  • Retinal Rod Photoreceptor Cells
  • Retinal Cone Photoreceptor Cells
  • Neurology & Neurosurgery
  • Neural Pathways
  • Membrane Potentials
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Banin, E., Cideciyan, A. V., Alemán, T. S., Petters, R. M., Wong, F., Milam, A. H., & Jacobson, S. G. (1999). Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. Neuron, 23(3), 549–557. https://doi.org/10.1016/s0896-6273(00)80807-7
Banin, E., A. V. Cideciyan, T. S. Alemán, R. M. Petters, F. Wong, A. H. Milam, and S. G. Jacobson. “Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development.Neuron 23, no. 3 (July 1999): 549–57. https://doi.org/10.1016/s0896-6273(00)80807-7.
Banin E, Cideciyan AV, Alemán TS, Petters RM, Wong F, Milam AH, et al. Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. Neuron. 1999 Jul;23(3):549–57.
Banin, E., et al. “Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development.Neuron, vol. 23, no. 3, July 1999, pp. 549–57. Pubmed, doi:10.1016/s0896-6273(00)80807-7.
Banin E, Cideciyan AV, Alemán TS, Petters RM, Wong F, Milam AH, Jacobson SG. Retinal rod photoreceptor-specific gene mutation perturbs cone pathway development. Neuron. 1999 Jul;23(3):549–557.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

July 1999

Volume

23

Issue

3

Start / End Page

549 / 557

Location

United States

Related Subject Headings

  • Synapses
  • Swine
  • Rhodopsin
  • Retinitis Pigmentosa
  • Retinal Rod Photoreceptor Cells
  • Retinal Cone Photoreceptor Cells
  • Neurology & Neurosurgery
  • Neural Pathways
  • Membrane Potentials
  • Humans