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Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat.

Publication ,  Journal Article
Green, GM; Taguchi, S; Friestman, J; Chey, WY; Liddle, RA
Published in: Am J Physiol
June 1989

The role of fat in regulation of pancreatic secretion was studied in conscious rats by measuring pancreatic secretion and plasma cholecystokinin (CCK) and secretin responses to intraluminal infusion of fat, protein, or trypsin inhibitor via the duodenum. In rats with pancreatic juice continuously returned to the intestine, intraduodenal infusion of 20% emulsified fat (Liposyn), 10% casein, and 0.4% ovomucoid trypsin inhibitor (OMTI) stimulated equivalent increases of approximately threefold in pancreatic protein output. Proglumide reduced fat-stimulated pancreatic protein secretion by greater than 90% but did not inhibit the response to OMTI. Fat significantly increased plasma CCK from basal levels of 0.5 pM to 2-3 pM, but it was a weaker stimulant of CCK secretion than casein (peak CCK levels greater than 10 pM) or OMTI (peak CCK levels 5-6 pM). Fat significantly stimulated secretin release (21.7 pM) compared with casein (6.8 pM), OMTI (4.4 pM), and NaCl (3.5 pM). The inhibition of fat-stimulated pancreatic secretion by proglumide indicates that the small amounts of CCK released by fat are necessary for a normal pancreatic response, suggesting that this response may be the result of potentiation between secretin and small amounts of CCK.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1989

Volume

256

Issue

6 Pt 1

Start / End Page

G1016 / G1021

Location

United States

Related Subject Headings

  • Secretin
  • Reference Values
  • Rats, Inbred Strains
  • Rats
  • Proglumide
  • Pancreatic Juice
  • Male
  • Kinetics
  • Dietary Fats
  • Cholecystokinin
 

Citation

APA
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MLA
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Green, G. M., Taguchi, S., Friestman, J., Chey, W. Y., & Liddle, R. A. (1989). Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat. Am J Physiol, 256(6 Pt 1), G1016–G1021. https://doi.org/10.1152/ajpgi.1989.256.6.G1016
Green, G. M., S. Taguchi, J. Friestman, W. Y. Chey, and R. A. Liddle. “Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat.Am J Physiol 256, no. 6 Pt 1 (June 1989): G1016–21. https://doi.org/10.1152/ajpgi.1989.256.6.G1016.
Green GM, Taguchi S, Friestman J, Chey WY, Liddle RA. Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat. Am J Physiol. 1989 Jun;256(6 Pt 1):G1016–21.
Green, G. M., et al. “Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat.Am J Physiol, vol. 256, no. 6 Pt 1, June 1989, pp. G1016–21. Pubmed, doi:10.1152/ajpgi.1989.256.6.G1016.
Green GM, Taguchi S, Friestman J, Chey WY, Liddle RA. Plasma secretin, CCK, and pancreatic secretion in response to dietary fat in the rat. Am J Physiol. 1989 Jun;256(6 Pt 1):G1016–G1021.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1989

Volume

256

Issue

6 Pt 1

Start / End Page

G1016 / G1021

Location

United States

Related Subject Headings

  • Secretin
  • Reference Values
  • Rats, Inbred Strains
  • Rats
  • Proglumide
  • Pancreatic Juice
  • Male
  • Kinetics
  • Dietary Fats
  • Cholecystokinin