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Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.

Publication ,  Journal Article
Rushakoff, RA; Goldfine, ID; Beccaria, LJ; Mathur, A; Brand, RJ; Liddle, RA
Published in: J Clin Endocrinol Metab
February 1993

The plasma cholecystokinin (CCK) response to a test meal was studied in 16 control subjects and 15 patients with noninsulin-dependent diabetes mellitus (NIDDM). Basal CCK levels were approximately 1 pmol in both groups. However, after the test meal, plasma CCK levels were 2-fold greater in the controls when compared to the diabetics. In controls, CCK levels maximally increased by 5.6 +/- 0.8 pmol (mean +/- SEM) 10 min after feeding, whereas in the NIDDM patients this value was 1.9 +/- 0.6 pmol (P < 0.001). After the test meal, the normal subjects showed no postprandial rise in blood glucose, whereas the diabetic patient showed a rise of 2.6 +/- 0.7 mmol. To determine whether the decreased CCK levels may have been related to the postprandial hyperglycemia, 7 diabetic subjects were infused with CCK. With this CCK infusion, postprandial glucose levels did not rise. These data suggest, therefore: 1) a role for cholecystokinin in regulating postprandial hyperglycemia in man, 2) abnormalities in CCK secretion occur in NIDDM and may contribute to the hyperglycemia seen in this disease.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

February 1993

Volume

76

Issue

2

Start / End Page

489 / 493

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Insulin
  • Hyperglycemia
  • Humans
  • Food
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Cholecystokinin
 

Citation

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Rushakoff, R. A., Goldfine, I. D., Beccaria, L. J., Mathur, A., Brand, R. J., & Liddle, R. A. (1993). Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. J Clin Endocrinol Metab, 76(2), 489–493. https://doi.org/10.1210/jcem.76.2.8432795
Rushakoff, R. A., I. D. Goldfine, L. J. Beccaria, A. Mathur, R. J. Brand, and R. A. Liddle. “Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.J Clin Endocrinol Metab 76, no. 2 (February 1993): 489–93. https://doi.org/10.1210/jcem.76.2.8432795.
Rushakoff RA, Goldfine ID, Beccaria LJ, Mathur A, Brand RJ, Liddle RA. Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. J Clin Endocrinol Metab. 1993 Feb;76(2):489–93.
Rushakoff, R. A., et al. “Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia.J Clin Endocrinol Metab, vol. 76, no. 2, Feb. 1993, pp. 489–93. Pubmed, doi:10.1210/jcem.76.2.8432795.
Rushakoff RA, Goldfine ID, Beccaria LJ, Mathur A, Brand RJ, Liddle RA. Reduced postprandial cholecystokinin (CCK) secretion in patients with noninsulin-dependent diabetes mellitus: evidence for a role for CCK in regulating postprandial hyperglycemia. J Clin Endocrinol Metab. 1993 Feb;76(2):489–493.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

February 1993

Volume

76

Issue

2

Start / End Page

489 / 493

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Insulin
  • Hyperglycemia
  • Humans
  • Food
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
  • Cholecystokinin