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The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake.

Publication ,  Journal Article
Ascoli, M; Liddle, RA; Puett, D
Published in: Mol Cell Endocrinol
July 1975

The kinetics of plasma clearance, tissue uptake, and urinary excretion of tritiated ovine pituitary luteinizing hormone in adult male rats are reported. Most of the intravenously injected tritiated gonadotropin is cleared from circulation with a half-life of five minutes, and this is independent of the injected amount of hormone over a wide dose range. It was found that the hormone is rapidly removed from circulation by the kidneys, probably by glomerular filtration, and excreted in the urine. The radioactivity present in the urine is associated with material of the same molecular size as the native hormone and, moreover, the urinary hormone retains a significant amount of biological activity. A small amount of the hormone is catabolized by the kidney and liver, and our data suggest that this occurs in the cortex and hepatocytes, respectively.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

July 1975

Volume

3

Issue

1

Start / End Page

21 / 36

Location

Ireland

Related Subject Headings

  • Time Factors
  • Testosterone
  • Testis
  • Sheep
  • Serum Albumin, Bovine
  • Receptors, Cell Surface
  • Rats
  • Pituitary Gland
  • Organ Specificity
  • Male
 

Citation

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Ascoli, M., Liddle, R. A., & Puett, D. (1975). The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. Mol Cell Endocrinol, 3(1), 21–36. https://doi.org/10.1016/0303-7207(75)90029-5
Ascoli, M., R. A. Liddle, and D. Puett. “The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake.Mol Cell Endocrinol 3, no. 1 (July 1975): 21–36. https://doi.org/10.1016/0303-7207(75)90029-5.
Ascoli M, Liddle RA, Puett D. The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. Mol Cell Endocrinol. 1975 Jul;3(1):21–36.
Ascoli, M., et al. “The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake.Mol Cell Endocrinol, vol. 3, no. 1, July 1975, pp. 21–36. Pubmed, doi:10.1016/0303-7207(75)90029-5.
Ascoli M, Liddle RA, Puett D. The metabolism of luteinizing hormone. Plasma clearance, urinary excretion, and tissue uptake. Mol Cell Endocrinol. 1975 Jul;3(1):21–36.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

July 1975

Volume

3

Issue

1

Start / End Page

21 / 36

Location

Ireland

Related Subject Headings

  • Time Factors
  • Testosterone
  • Testis
  • Sheep
  • Serum Albumin, Bovine
  • Receptors, Cell Surface
  • Rats
  • Pituitary Gland
  • Organ Specificity
  • Male