Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction.
Publication
, Journal Article
Betcher-Lange, SL; Coughlan, MP; Rajagopalan, KV
Published in: J Biol Chem
September 25, 1979
Xanthine dehydrogenase engaged in catalyzing the oxidation of substrate by oxygen is repidly inactivated by the hydrogen peroxide generated during the reaction. Experimental evidence shows that peroxide reacts more readily with the reduced than with the oxidized form of the enzyme. Inactivation results from modification of the cyanolysable sulfur present at the molybdenum center.
Duke Scholars
Published In
J Biol Chem
ISSN
0021-9258
Publication Date
September 25, 1979
Volume
254
Issue
18
Start / End Page
8825 / 8829
Location
United States
Related Subject Headings
- Xanthine Dehydrogenase
- Oxidation-Reduction
- Liver
- Kinetics
- Ketone Oxidoreductases
- Hydrogen Peroxide
- Cyanides
- Biochemistry & Molecular Biology
- Arsenic
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Betcher-Lange, S. L., Coughlan, M. P., & Rajagopalan, K. V. (1979). Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction. J Biol Chem, 254(18), 8825–8829.
Betcher-Lange, S. L., M. P. Coughlan, and K. V. Rajagopalan. “Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction.” J Biol Chem 254, no. 18 (September 25, 1979): 8825–29.
Betcher-Lange SL, Coughlan MP, Rajagopalan KV. Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction. J Biol Chem. 1979 Sep 25;254(18):8825–9.
Betcher-Lange, S. L., et al. “Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction.” J Biol Chem, vol. 254, no. 18, Sept. 1979, pp. 8825–29.
Betcher-Lange SL, Coughlan MP, Rajagopalan KV. Syncatalytic modification of chicken liver xanthine dehydrogenase by hydrogen peroxide. The nature of the reaction. J Biol Chem. 1979 Sep 25;254(18):8825–8829.
Published In
J Biol Chem
ISSN
0021-9258
Publication Date
September 25, 1979
Volume
254
Issue
18
Start / End Page
8825 / 8829
Location
United States
Related Subject Headings
- Xanthine Dehydrogenase
- Oxidation-Reduction
- Liver
- Kinetics
- Ketone Oxidoreductases
- Hydrogen Peroxide
- Cyanides
- Biochemistry & Molecular Biology
- Arsenic
- Animals