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Detection of trisomy 12 by fluorescence in situ hybridization on archival cytopathologic material in chronic lymphocytic leukemia/small lymphocytic lymphoma.

Publication ,  Journal Article
Liu, K; Dodd, LG; Powers, JA; Bigner, SH
Published in: Acta Cytol
2000

OBJECTIVE: To evaluate fluorescence in situ hybridization (FISH) for the detection of trisomy 12 in archival cytologic specimens of chronic lymphocytic leukemia/small lymphocytic lymphoma. STUDY DESIGN: The cytopathology database was searched for all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma. Six cases of chronic lymphocytic leukemia/small lymphocytic lymphoma obtained by fine needle aspiration and one case of small lymphocytic lymphoma with plasmacytoid features were analyzed for trisomy 12 by FISH. These cases had been archived between 1 week to 16 months prior to analysis. RESULTS: We detected trisomy 12 in four of the six cases of small lymphocytic lymphoma/chronic lymphocytic leukemia. The case of small lymphocytic lymphoma with plasmacytoid features was negative for trisomy 12. CONCLUSION: Detection of trisomy 12 by FISH can be effectively performed on routinely prepared, stained and coverslipped archival cytologic material.

Duke Scholars

Published In

Acta Cytol

DOI

ISSN

0001-5547

Publication Date

2000

Volume

44

Issue

3

Start / End Page

368 / 374

Location

Switzerland

Related Subject Headings

  • Trisomy
  • Pathology
  • Middle Aged
  • Male
  • Leukemia, Lymphoid
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • In Situ Hybridization, Fluorescence
  • Humans
  • Female
  • Chronic Disease
 

Citation

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ICMJE
MLA
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Journal cover image

Published In

Acta Cytol

DOI

ISSN

0001-5547

Publication Date

2000

Volume

44

Issue

3

Start / End Page

368 / 374

Location

Switzerland

Related Subject Headings

  • Trisomy
  • Pathology
  • Middle Aged
  • Male
  • Leukemia, Lymphoid
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • In Situ Hybridization, Fluorescence
  • Humans
  • Female
  • Chronic Disease